Department of Chemistry, Rice University, Houston, TX 77005, USA.
Nanotechnology. 2012 Feb 10;23(5):055602. doi: 10.1088/0957-4484/23/5/055602. Epub 2012 Jan 11.
Stable iron nanoparticles have been synthesized from naturally occurring and abundant Fe-containing bio-precursors, namely hemoglobin and myoglobin. The formation of stable iron nanoparticles was achieved through a one-pot, single-phase chemical reduction approach. The reduction of iron ions present in the bio-precursors was carried out at room temperature and avoids the use of harsh chemical reagents. The size distribution of the product falls into the narrow 2-5 nm range and the particles were found to be crystalline. This method can be a valuable synthetic approach for producing bio-conjugated nanoparticle systems for biological applications.
已从天然存在且丰富的含 Fe 生物前体(即血红蛋白和肌红蛋白)合成了稳定的铁纳米颗粒。通过一锅、单相化学还原法实现了稳定铁纳米颗粒的形成。在室温下进行生物前体中存在的铁离子的还原,避免了使用苛刻的化学试剂。产物的粒径分布落入狭窄的 2-5nm 范围内,并且发现颗粒是结晶的。该方法可以成为用于生产用于生物应用的生物缀合纳米颗粒系统的有价值的合成方法。