肾细胞癌的晚期与副肿瘤综合征之间是否存在关联？

Is there an association between advanced stage of renal cell carcinoma and paraneoplastic syndrome?

机构信息

Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.

出版信息

Med Princ Pract. 2012;21(4):370-4. doi: 10.1159/000334873. Epub 2012 Jan 6.

DOI:10.1159/000334873

PMID:22237047

Abstract

OBJECTIVE

To investigate any association between renal cell carcinoma (RCC) and paraneoplastic syndromes (PNS).

SUBJECTS AND METHODS

The retrospective analysis included 1,028 patients of Chinese Han nationality with resectable RCC and PNS. The PNS included elevated erythrocyte sedimentation rate (ESR), hypertension, cachexia, anemia, pyrexia, abnormal liver function, hypercalcemia, polycythemia, varicocele and neuromyopathy. Staging was categorized as local (T1-2N0M0) and locally advanced (T3-4NxM0).

RESULTS

Among patients with at least one PNS, elevated ESR (p = 0.008), cachexia (p = 0.000), varicocele (p = 0.000) and pyrexia (p = 0.021) were related to advanced stage of RCC. Among patients with only one PNS, hypertension (p = 0.012) and hypercalcemia (p = 0.000) were related to advanced stage. The remaining PNS were not associated with tumor stage.

CONCLUSION

Pyrexia, elevated ESR, cachexia and varicocele were related to advanced RCC. Hypertension and hypercalcemia occurring as single PNS, although also correlated with advanced stage, require further investigation.

摘要

目的

探讨肾细胞癌（RCC）与副肿瘤综合征（PNS）之间的任何关联。

对象和方法

回顾性分析包括 1028 例汉族可切除 RCC 和 PNS 患者。PNS 包括红细胞沉降率（ESR）升高、高血压、恶病质、贫血、发热、肝功能异常、高钙血症、红细胞增多症、精索静脉曲张和神经肌肉病。分期分为局部（T1-2N0M0）和局部晚期（T3-4NxM0）。

结果

在至少有一种 PNS 的患者中，ESR 升高（p = 0.008）、恶病质（p = 0.000）、精索静脉曲张（p = 0.000）和发热（p = 0.021）与 RCC 的晚期阶段有关。在仅有一种 PNS 的患者中，高血压（p = 0.012）和高钙血症（p = 0.000）与晚期有关。其余的 PNS 与肿瘤分期无关。