Department of Pathology, Miyagi Cancer Center, Natori City, Japan.
Pathol Int. 2012 Feb;62(2):149-52. doi: 10.1111/j.1440-1827.2011.02759.x. Epub 2011 Nov 30.
Mammary Analog Secretory Carcinoma (MASC) is a new entity of malignant salivary gland tumors that morphologically resembles mammary secretory carcinoma and carries the identical ETV6-NTRK3 fusion gene. We report our first case of MASC in Japan occurring in the parotid gland of a 37-year-old female patient with a t (12; 15) (p13; q25) translocation. Histologically, the tumor was composed of monomorphic cuboidal cells with low-grade vesicular nuclei and pale eosinophilic cytoplasm, and formed microcystic and tubular spaces with periodic acid-Schiff-positive secretion. Immunohistochemically, the tumor cells tested positive for cytokeratin, vimentin, and S-100 protein. MASC is a morphological mimicker of acinic cell carcinoma, but is a distinct neoplasm characterized by a specific chromosomal translocation. An accumulation of similar case studies is mandatory in order to clarify biological behaviors.
乳腺样分泌性癌（MASC）是一种新的恶性涎腺肿瘤实体，在形态上类似于乳腺分泌性癌，并携带相同的 ETV6-NTRK3 融合基因。我们报告了首例在日本发生于 37 岁女性患者腮腺的 MASC，该患者存在 t（12；15）（p13；q25）易位。组织学上，肿瘤由形态单一的柱状细胞组成，核呈低级别泡状，胞质呈淡嗜酸性，形成微囊和管状腔隙，伴 PAS 阳性分泌。免疫组化染色显示，肿瘤细胞 CK、波形蛋白和 S-100 蛋白阳性。MASC 在形态上类似于腺泡细胞癌，但它是一种具有特定染色体易位的独特肿瘤。为了阐明生物学行为，有必要积累更多类似的病例研究。
