Reading School of Pharmacy, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
Macromol Rapid Commun. 2012 Feb 27;33(4):332-6. doi: 10.1002/marc.201100742. Epub 2012 Jan 18.
It has been found that hydrogels may be formed by microwave irradiation of aqueous solutions containing appropriate combinations of polymers. This new method of hydrogel synthesis yields sterile hydrogels without the use of monomers, eliminating the need for the removal of unreacted species from the final product. Results for two particularly successful combinations, poly(vinyl alcohol) with either poly(acrylic acid) or poly(methylvinylether-alt-maleic anhydride), are presented. Irradiation using temperatures of 100-150 °C was found to yield hydrogels with large equilibrium swelling degrees of 500-1000 g g(-1) . Material leached from both types of hydrogel shows little cytotoxicity towards HT29 cells.
已经发现，含有适当聚合物组合的水凝胶可以通过微波辐照水溶液来形成。这种新的水凝胶合成方法无需使用单体即可生成无菌水凝胶，从而无需从最终产物中去除未反应的物质。介绍了两种特别成功的组合，即聚乙烯醇与聚丙烯酸或聚甲基乙烯基醚-马来酸酐。发现使用 100-150°C 的温度进行辐照可以得到平衡溶胀度为 500-1000g/g 的水凝胶。从这两种水凝胶中浸出的材料对 HT29 细胞的细胞毒性很小。
