一种具有金刚烷骨架的新苯甲酰基间苯三酚衍生物和其他来自藤黄属的成分：对中性粒细胞促炎反应的影响。

A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from Garcinia multiflora: effects on neutrophil pro-inflammatory responses.

机构信息

Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

出版信息

Chem Biodivers. 2012 Jan;9(1):99-105. doi: 10.1002/cbdv.201100006.

DOI:10.1002/cbdv.201100006

Abstract

A novel benzoylphloroglucinol derivative, garcimultiflorone D (1), with an unusual adamantyl-caged skeleton was isolated from the fruits of Garcinia multiflora, together with four known compounds. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Garcimultiflorone D (1) exhibited inhibitory activities with IC(50) values of 7.21±1.07 and 6.01±0.37 μg/ml against fMLP/CB-induced superoxide anion generation and elastase release, respectively.

摘要

从藤黄属植物 Garcinia multiflora 的果实中分离得到了一种新型的苯甲酰基间苯三酚衍生物，garcimultiflorone D（1），具有不寻常的金刚烷笼状骨架，此外还分离得到了四个已知化合物。通过广泛的 1D/2D-NMR 和质谱分析确定了 1 的结构。Garcimultiflorone D（1）对 fMLP/CB 诱导的超氧阴离子生成和弹性蛋白酶释放分别表现出抑制活性，IC50 值为 7.21±1.07 和 6.01±0.37μg/ml。