Aceros Juan, Yin Ming, Borton David A, Patterson William R, Nurmikko Arto V
School of Engineering, Brown University, Providence, RI 02912, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2300-6. doi: 10.1109/IEMBS.2011.6090579.
We present a fully implantable, wireless, neurosensor for multiple-location neural interface applications. The device integrates two independent 16-channel intracortical microelectrode arrays and can simultaneously acquire 32 channels of broadband neural data from two separate cortical areas. The system-on-chip implantable sensor is built on a flexible Kapton polymer substrate and incorporates three very low power subunits: two cortical subunits connected to a common subcutaneous subunit. Each cortical subunit has an ultra-low power 16-channel preamplifier and multiplexer integrated onto a cortical microelectrode array. The subcutaneous epicranial unit has an inductively coupled power supply, two analog-to-digital converters, a low power digital controller chip, and microlaser-based infrared telemetry. The entire system is soft encapsulated with biocompatible flexible materials for in vivo applications. Broadband neural data is conditioned, amplified, and analog multiplexed by each of the cortical subunits and passed to the subcutaneous component, where it is digitized and combined with synchronization data and wirelessly transmitted transcutaneously using high speed infrared telemetry.
我们展示了一种用于多位置神经接口应用的完全可植入式无线神经传感器。该设备集成了两个独立的16通道皮层内微电极阵列，能够同时从两个不同的皮层区域采集32通道的宽带神经数据。片上系统可植入传感器基于柔性聚酰亚胺聚合物基板构建，并包含三个极低功耗的子单元：两个与一个共同的皮下子单元相连的皮层子单元。每个皮层子单元都有一个集成在皮层微电极阵列上的超低功耗16通道前置放大器和多路复用器。皮下颅骨外单元有一个电感耦合电源、两个模数转换器、一个低功耗数字控制器芯片以及基于微激光的红外遥测技术。整个系统用生物相容性柔性材料进行软封装，用于体内应用。宽带神经数据由每个皮层子单元进行调节、放大和模拟多路复用，然后传递到皮下组件，在那里进行数字化处理，并与同步数据合并，再使用高速红外遥测技术经皮无线传输。
