使用多通道前庭假体对龙猫的半规管进行慢性刺激：对运动和角前庭眼反射的影响
Chronic stimulation of the semicircular canals using a multichannel vestibular prosthesis: effects on locomotion and angular vestibulo-ocular reflex in chinchillas.
作者信息
Sun Daniel Q, Rahman Mehdi A, Fridman Gene, Dai Chenkai, Chiang Bryce, Della Santina Charles C
机构信息
Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:3519-23. doi: 10.1109/IEMBS.2011.6090584.
Abstract
Bilateral loss of vestibular sensation causes difficulty maintaining stable vision, posture and gait. An implantable prosthesis that partly restores vestibular sensation could significantly improve quality of life for individuals disabled by this disorder. We have developed a head-mounted multichannel vestibular prosthesis (MVP) that restores sufficient semicircular canal function to recreate a 3D angular vestibulo-ocular reflex (aVOR). In this study, we evaluated effects of chronic MVP stimulation on locomotion in chinchillas. Two of three animals examined exhibited significant improvements in both locomotion and aVOR.
摘要
双侧前庭感觉丧失会导致难以维持稳定的视力、姿势和步态。一种可部分恢复前庭感觉的植入式假体能够显著改善受这种疾病影响的残疾人的生活质量。我们开发了一种头戴式多通道前庭假体（MVP），它能恢复足够的半规管功能以重建三维角前庭眼反射（aVOR）。在本研究中，我们评估了慢性MVP刺激对龙猫运动的影响。三只接受检查的动物中有两只在运动和aVOR方面均表现出显著改善。
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