异种移植免疫耐受的研究进展。
Current progress in xenogeneic tolerance.
机构信息
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.
出版信息
Curr Opin Organ Transplant. 2012 Apr;17(2):168-73. doi: 10.1097/MOT.0b013e32835090f6.
PURPOSE OF REVIEW
The present review updates the current status of research regarding the immunologic responses of the recipient following xenotransplantation. Additionally, we present the recent progress with attempts to induce xenogeneic tolerance induction.
RECENT FINDINGS
There continues to be great interest in xenotransplantation. Recently, descriptions of the mechanisms responsible for attempted T-cell xenogeneic tolerance in both large and small animal models have improved xenogeneic graft survivals. Additionally, the cellular signaling mechanisms, such as those involving CD39, CD44, and CD47, are proving to be highly important. Using the mixed chimerism approach to tolerance in xenogeneic model may be encouraging, especially given the recent clarification of the role for macrophage-induced phagocytosis of xenogeneic donor cells.
SUMMARY
Induction of tolerance to xenogeneic antigens has been accomplished only in small animals; however, graft survivals in large animal models continue to improve. Further clarification of both the adaptive and innate immune responses to xenogeneic antigens is required for success to continue.
目的综述
本综述更新了受体在异种移植后免疫反应的最新研究现状。此外，我们还介绍了诱导异种免疫耐受的最新进展。
最近发现
人们对异种移植仍有浓厚兴趣。最近，在大、小动物模型中描述的负责尝试诱导 T 细胞异种免疫耐受的机制，提高了异种移植物的存活率。此外，细胞信号转导机制，如涉及 CD39、CD44 和 CD47 的机制，被证明是非常重要的。在异种模型中使用混合嵌合体方法来诱导耐受可能是令人鼓舞的，尤其是考虑到最近对巨噬细胞诱导吞噬异种供体细胞的作用的阐明。
摘要
仅在小动物中诱导对异种抗原的耐受已取得成功；然而，大动物模型中的移植物存活率仍在提高。需要进一步阐明对异种抗原的适应性和固有免疫反应，以继续取得成功。
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