Veterans Engineering Resource Center, White River Junction, Vermont 05009, USA.
Brain Stimul. 2012 Jan;5(1):38-43. doi: 10.1016/j.brs.2011.02.002. Epub 2011 Mar 3.
Posttraumatic stress disorder (PTSD) is a commonly occurring and often debilitating psychiatric condition. There currently is not definitive information regarding the efficacy of repetitive transcranial magnetic stimulation (rTMS) for PTSD.
This study seeks to examine the efficacy of rTMS for PTSD.
Twenty subjects with PTSD were randomly assigned to receive either 10 rTMS sessions delivered at 1 Hz to the right dorsolateral prefrontal cortex (DLPRC) or 10 sham rTMS sessions to the same area. A blinded rater assessed PTSD, depressive, anxiety, and neurocognitive symptoms before treatment, after the treatment series, and during a 2-month follow-up period.
Trancranial magnetic stimulation delivered at 1 Hz to the right DLPRC resulted in statistically and clinically significant improvements in core PTSD symptoms and depressive symptoms compared with sham treatments. The effectiveness showed some degradation during the 2 months after treatments were stopped.
This blinded sham controlled trial supports the efficacy of 10 sessions of right DLPRC rTMS delivered at 1 Hz for the treatment of PTSD symptoms.
创伤后应激障碍（PTSD）是一种常见且常使人衰弱的精神疾病。目前，关于重复经颅磁刺激（rTMS）治疗 PTSD 的疗效尚无明确信息。
本研究旨在探讨 rTMS 治疗 PTSD 的疗效。
20 名 PTSD 患者被随机分配接受 10 次 1 Hz 的 rTMS 治疗或 10 次假 rTMS 治疗，刺激部位为右侧背外侧前额叶皮质（DLPRC）。一位盲法评估者在治疗前、治疗系列结束后和 2 个月随访期间评估 PTSD、抑郁、焦虑和神经认知症状。
与假刺激相比，1 Hz 的 rTMS 刺激右侧 DLPRC 可显著改善 PTSD 的核心症状和抑郁症状，且具有统计学意义和临床意义。在治疗停止后的 2 个月内，疗效有所下降。
这项盲法假刺激对照试验支持 10 次 1 Hz 的右侧 DLPRC rTMS 治疗 PTSD 症状的有效性。
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