转化生长因子β1 过表达与肝癌的侵袭性密切相关。

Transforming growth factor beta 1 overexpression is closely related to invasiveness of hepatocellular carcinoma.

机构信息

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea.

出版信息

Oncology. 2012;82(1):11-8. doi: 10.1159/000335605. Epub 2012 Jan 24.

DOI:10.1159/000335605

PMID:22269311

Abstract

OBJECTIVES

The study was aimed to investigate the relationship between plasma transforming growth factor beta 1 (TGF-β(1)) expression and the characteristics of hepatocellular carcinoma (HCC).

METHODS

Five hundred and seventy-one patients with HCC were subjected. Plasma TGF-β(1) levels were measured by enzyme-linked immunosorbent assay at diagnosis and compared in accordance with clinical and radiological characteristics.

RESULTS

Plasma TGF-β(1) levels were significantly higher in the diffuse infiltrative type (n = 159) than in the nodular type of HCC (n = 412; 3.94 ± 0.34 vs. 3.79 ± 0.29 log(10) pg/ml; p < 0.001). They were much higher in patients with portal vein thrombosis or extrahepatic metastasis than in those without (3.88 ± 0.34 vs. 3.81 ± 0.29 log(10) pg/ml, p = 0.008; 3.94 ± 0.35 vs. 3.82 ± 0.30 log(10) pg/ml, p = 0.013, respectively). Also, plasma TGF-β(1) levels showed a positive correlation with the size of HCC (r = 0.014, p < 0.001). Additionally, plasma TGF-β(1) levels were inversely related to the survival periods (p < 0.001).

CONCLUSION

TGF-β(1) was overexpressed in invasive types of HCC and it may be involved in the rapid progression of HCC.

摘要

目的

本研究旨在探讨血浆转化生长因子β1（TGF-β1）表达与肝细胞癌（HCC）特征之间的关系。

方法

对 571 例 HCC 患者进行检测。采用酶联免疫吸附试验（ELISA）检测患者诊断时的血浆 TGF-β1 水平，并根据临床和影像学特征进行比较。

结果

弥漫浸润型（n = 159）患者的血浆 TGF-β1 水平明显高于结节型 HCC 患者（n = 412；3.94 ± 0.34 vs. 3.79 ± 0.29 log（10）pg/ml；p < 0.001）。有门静脉血栓形成或肝外转移的患者的血浆 TGF-β1 水平明显高于无门静脉血栓形成或肝外转移的患者（3.88 ± 0.34 vs. 3.81 ± 0.29 log（10）pg/ml，p = 0.008；3.94 ± 0.35 vs. 3.82 ± 0.30 log（10）pg/ml，p = 0.013）。此外，血浆 TGF-β1 水平与 HCC 的大小呈正相关（r = 0.014，p < 0.001）。此外，血浆 TGF-β1 水平与生存时间呈负相关（p < 0.001）。