Alghamdi Khalid M, Al-Mubarak Luluah A
Colleg of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Drugs Dermatol. 2012 Feb;11(2):252-5.
Neurothekeoma is a rare neoplasm assigned to the broad category of benign peripheral nerve sheath tumors. Its cell of origin is still unknown, but most ultrastructural and immunohistochemical studies have favoured the Schwann cell perineurium or fibroblast. Neurothekeoma most commonly presents in females, especially in the second and third decades of life. Typically it presents as an asymptomatic solitary, firm, flesh-coloured or hyperpigmented slow-growing papule or nodule that involves the skin and superficial subcutis. It usually involves the face, neck, arm or shoulder but can also involve extracutaneous sites. Neurothekeoma occurs in myxoid (classic), cellular and intermediate (mixed) variants. Here, we report a 45-year-old male patient presenting with a nodule on the nose that was found to be a myxoid variant of neurothekeoma. It was treated with a simple shave excision followed by removal of the lobulated deeper part by forceps. He had no recurrence after three years of follow-up. To the best of our knowledge, this is the first case of a myxoid neurothekeoma of the nose to be reported in the Middle East.
神经鞘黏液瘤是一种罕见的肿瘤，属于良性周围神经鞘瘤这一广泛类别。其起源细胞仍不清楚，但大多数超微结构和免疫组织化学研究支持其起源于雪旺细胞、神经束膜或成纤维细胞。神经鞘黏液瘤最常见于女性，尤其是在生命的第二个和第三个十年。通常表现为无症状的孤立性、质地硬、肉色或色素沉着的缓慢生长丘疹或结节，累及皮肤和皮下浅层。它通常累及面部、颈部、手臂或肩部，但也可累及皮肤外部位。神经鞘黏液瘤有黏液样（经典型）、细胞型和中间型（混合型）变体。在此，我们报告一名45岁男性患者，其鼻部出现一个结节，经检查发现是神经鞘黏液瘤的黏液样变体。采用简单的刮除术进行治疗，随后用镊子切除分叶状的深部组织。随访三年后他未复发。据我们所知，这是中东地区首例关于鼻部黏液样神经鞘黏液瘤的报道。
