Folsland B, Skulberg A, Halvorsen P, Helgesen K G
Department of Anaesthesiology, Ulleval Hospital, Oslo, Norway.
J Int Med Res. 1990 Jul-Aug;18(4):305-14. doi: 10.1177/030006059001800407.
The analgesic efficacy and safety of single doses of 10 mg and 30 mg ketorolac tromethamine and 100 mg pethidine were evaluated in a double-blind, parallel-group study. The drugs were administered intramuscularly to patients experiencing moderate, severe or very severe pain immediately following major abdominal surgery. A total of 129 patients were randomly assigned to receive either active drug (n = 32 for each treatment group) or placebo (n = 33), and the patients assessed pain intensity and pain relief on a visual analogue scale at regular intervals over the following 8 h. During the first 2 h, pethidine had a more rapid onset of action than ketorolac or placebo, and thereafter 100 mg pethidine and 30 mg ketorolac were equally effective. Ketorolac, at a dose of 10 or 30 mg, and 100 mg pethidine were clinically and statistically more effective than placebo, with 30 mg ketorolac having a similar efficacy to 100 mg pethidine over the 8-h study period and 10 mg ketorolac being slightly less effective than 30 mg ketorolac. No serious adverse events were reported.
在一项双盲、平行组研究中，评估了单剂量10毫克和30毫克酮咯酸氨丁三醇以及100毫克哌替啶的镇痛效果和安全性。在腹部大手术后，立即对经历中度、重度或极重度疼痛的患者进行肌肉注射给药。共有129名患者被随机分配接受活性药物（每个治疗组n = 32）或安慰剂（n = 33），患者在接下来的8小时内定期用视觉模拟量表评估疼痛强度和疼痛缓解情况。在最初的2小时内，哌替啶的起效速度比酮咯酸或安慰剂更快，此后100毫克哌替啶和30毫克酮咯酸的效果相当。10毫克或30毫克剂量的酮咯酸以及100毫克哌替啶在临床和统计学上比安慰剂更有效，在8小时的研究期间，30毫克酮咯酸与100毫克哌替啶的疗效相似，10毫克酮咯酸的效果略低于30毫克酮咯酸。未报告严重不良事件。
