Department of Diabetology and Nutritional Diseases, Medical Centre, University Hospital of Nîmes, 30240, Le Grau du Roi, France.
Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:46-53. doi: 10.1002/dmrr.2234.
Infection of foot ulcers is a common, often severe and costly complication in diabetes. Many factors linked to the host, mainly immune defects, neuropathy and arteriopathy, as well as bacteria-related factors, interact in a complex way and account for the susceptibility of diabetic individuals to foot infections, the severity of such infections and difficulty to treat them.
This article reviews these factors, in the light of data from the literature and from our own results.
DFIs are not as simple as previously suggested, and new concepts must be considered, especially the virulence potential of isolates and bacterial communications through biofilms.
The development of new tools from molecular biology is a critical step to better understand and manage these infections.
足部溃疡感染是糖尿病患者中一种常见的、通常较为严重且费用高昂的并发症。许多与宿主相关的因素，主要是免疫缺陷、神经病变和血管病变，以及与细菌相关的因素，以复杂的方式相互作用，导致糖尿病患者易患足部感染、感染的严重程度以及治疗的困难。
本文根据文献和我们自己的研究结果，综述了这些因素。
DFIs 并不像以前认为的那么简单，必须考虑新的概念，特别是分离株的毒力潜力和通过生物膜的细菌通讯。
从分子生物学开发新工具是更好地理解和管理这些感染的关键步骤。
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