体重指数与遗传性非息肉病性结直肠癌在韩国子宫内膜癌患者中患病率的相关性。

Correlation between body mass index and prevalence of hereditary nonpolyposis colorectal cancer in Korean patients with endometrial cancer.

机构信息

Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Republic of Korea.

出版信息

Int J Gynecol Cancer. 2012 Feb;22(2):267-72. doi: 10.1097/IGC.0b013e31823b3650.

DOI:10.1097/IGC.0b013e31823b3650

PMID:22274318

Abstract

OBJECTIVE

The purpose of the study was to investigate the relationship between body mass index (BMI) and hereditary nonpolyposis colorectal cancer (HNPCC) in Korean women with endometrial cancer.

METHODS

Among 227 patients with endometrial cancer in the study population, 20 patients (8.8%) had HNPCC. The patients were divided into 2 groups based on the BMI: nonobese (BMI ≤25 kg/m) and obese (BMI >25 kg/m); then the nonobese group was subdivided into 2 groups: normal weight (BMI <23 kg/m) and overweight (BMI, 23-25 kg/m). The distributions of BMI categories were compared between patients with sporadic endometrial cancer and with HNPCC-related endometrial cancer.

RESULTS

Among 207 patients with sporadic endometrial cancer, 119 (57.5%) were nonobese and 88 patients (42.5%) were obese. Of 20 patients with endometrial cancer related to HNPCC, 10 (50.0%) were nonobese and 10 (50.0%) were obese. In a subgroup analysis of only nonobese patients, 68 patients with sporadic endometrial cancer had normal weight and 51 were overweight. On the other hand, all 10 patients with HNPCC related to endometrial cancer had normal weight. There was no significant difference between the group with HNPCC-related endometrial cancer and the group with sporadic endometrial cancer according to BMI (P = 0.221). However, BMI proportions in HNPCC related to endometrial cancer were significantly different from those in sporadic endometrial cancer (P = 0.016). Among a subgroup of nonobese patients, the proportion of normal weight was significant higher in patients with HNPCC-related endometrial cancer compared to those in sporadic endometrial cancer (P = 0.006).

CONCLUSION

Body mass index was not different between sporadic endometrial cancer and HNPCC-related endometrial cancer in Koreans. However, BMI proportions in the patients with HNPCC related to endometrial cancer was significantly different from those in sporadic endometrial cancer. Specifically, among nonobese patients, the proportion of normal weight was significantly high in Korean women with HNPCC.

摘要

目的

本研究旨在探讨韩国女性子宫内膜癌患者的体重指数（BMI）与遗传性非息肉病性结直肠癌（HNPCC）之间的关系。

方法

在研究人群中的 227 名子宫内膜癌患者中，有 20 名（8.8%）患有 HNPCC。根据 BMI 将患者分为 2 组：非肥胖组（BMI≤25kg/m）和肥胖组（BMI>25kg/m）；然后将非肥胖组进一步分为 2 组：正常体重组（BMI<23kg/m）和超重组（BMI，23-25kg/m）。比较散发性子宫内膜癌患者和 HNPCC 相关子宫内膜癌患者的 BMI 类别分布。

结果

在 207 名散发性子宫内膜癌患者中，119 名（57.5%）为非肥胖，88 名（42.5%）为肥胖。在 20 名患有 HNPCC 相关子宫内膜癌的患者中，10 名（50.0%）为非肥胖，10 名（50.0%）为肥胖。仅在非肥胖患者的亚组分析中，68 名患有散发性子宫内膜癌的患者体重正常，51 名超重。另一方面，所有 10 名患有 HNPCC 相关子宫内膜癌的患者体重正常。根据 BMI，HNPCC 相关子宫内膜癌组与散发性子宫内膜癌组之间无显著差异（P=0.221）。然而，HNPCC 相关子宫内膜癌组的 BMI 比例与散发性子宫内膜癌组有显著差异（P=0.016）。在非肥胖患者的亚组中，HNPCC 相关子宫内膜癌患者的正常体重比例明显高于散发性子宫内膜癌患者（P=0.006）。