Department of Cardiothoracic Surgery, Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Curr Opin Cardiol. 2012 Mar;27(2):111-7. doi: 10.1097/HCO.0b013e32834fec29.
The optimal surgical treatment of chronic ischemic mitral regurgitation still is the subject of much debate in the surgical and cardiological communities. Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. In addition, not all patients improve. Remaining issues in this field relate to identification of patients who will benefit from treatment, and to further improve and individualize treatment modalities.
More data support the use of restrictive mitral annuloplasty and revascularization. New surgical techniques to improve mitral competence (posterior leaflet augmentation) and to promote left ventricular reverse remodeling in severely dilated hearts (addressing the subvalvular apparatus) are promising. Disease-specific annuloplasty rings have not (yet) proven additional value. New imaging modalities are available to assess the many components that constitute the complex pathophysiology of remodeling.
The remaining challenge for cardiologists and surgeons is how to integrate data from different imaging techniques that assess mitral valve geometry and left ventricular size, geometry, function and potential functional recovery in order to individualize and optimize the surgical approach to patients with chronic ischemic mitral regurgitation.
慢性缺血性二尖瓣反流的最佳手术治疗仍然是外科和心脏病学界争论的焦点。尽管联合限制性二尖瓣环成形术和血运重建术在改善临床状况、降低二尖瓣反流复发率和维持左心室逆重构方面取得了良好的效果,但仍未证明其具有生存获益。此外,并非所有患者都能得到改善。这一领域的遗留问题涉及到确定哪些患者将从治疗中获益,以及进一步改进和个体化治疗方式。
更多的数据支持采用限制性二尖瓣环成形术和血运重建术。改善二尖瓣功能(后叶瓣增强)和促进严重扩张心脏左心室逆重构的新技术(处理瓣下装置)具有很大的应用前景。特定疾病的瓣环成形环尚未(尚未)证明具有额外的价值。新的成像方式可用于评估构成重构复杂病理生理学的许多组成部分。
心脏病专家和外科医生面临的剩余挑战是如何整合来自不同成像技术的数据,这些技术可评估二尖瓣几何形状和左心室大小、几何形状、功能和潜在的功能恢复,以便对慢性缺血性二尖瓣反流患者进行个体化和优化手术治疗。