Heijink Dilara Savci, Urgun Kamran, Sav Aydin, Seker Askin, Konya Deniz
Department of Neurosurgery, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Turk Neurosurg. 2012;22(1):90-4. doi: 10.5137/1019-5149.JTN.2658-09.1.
Gliomas may rarely arise in the leptomeninges without any evidence of intraaxial involvement. A case of primary diffuse leptomeningeal gliomatosis (PDLG) histologically diagnosed as oligoastrocytoma is presented. A 50-year-old woman presented with nausea, vomiting and headache. Magnetic resonance imaging (MRI) of cranium and cervical region revealed dural thickening starting from the craniocervical junction to the level of C4 without any parenchymal lesions. CSF examination showed an increase in protein and decrease in glucose levels. There were neither any kind of atypical cells nor any kind of growth in bacterial cultures. The patient underwent biopsy at the level of C1 for diagnosis. The specimen was diagnosed as primary diffuse leptomeningeal gliomatosis, with phenotypic features of astrocytoma and oligodendroglioma.
胶质瘤很少起源于软脑膜，而无任何脑实质受累的证据。本文报告一例组织学诊断为少突星形细胞瘤的原发性弥漫性软脑膜胶质瘤病（PDLG）病例。一名50岁女性出现恶心、呕吐和头痛症状。头颅和颈部的磁共振成像（MRI）显示从颅颈交界处至C4水平的硬脑膜增厚，无任何实质病变。脑脊液检查显示蛋白质水平升高，葡萄糖水平降低。细菌培养中既未发现任何类型的非典型细胞，也未发现任何生长迹象。为明确诊断，患者在C1水平接受了活检。标本被诊断为原发性弥漫性软脑膜胶质瘤病，具有星形细胞瘤和少突胶质细胞瘤的表型特征。
