用抗抑郁药战胜癌症。
Defeating cancer with antidepressants.
作者信息
Lieb J
机构信息
127 Cumberland Road, Burlington, Vermont, USA.
出版信息
Ecancermedicalscience. 2008;2:88. doi: 10.3332/ecancer.2008.88. Epub 2008 Aug 21.
Abstract
Prostaglandins are ephemeral, infinitesimal signallers self-regulating every cell in the body, including those sub-serving mood and immunity. At first, they were perceived as a master switch, but now are believed to regulate every component of cellular micro-anatomy and physiology, including those of the organelles, cytoskeleton, proteins, enzymes, nucleic acids and mitochondria. Prostaglandins are responsible, paradoxically, for cell function and dysfunction. Excessive prostaglandin synthesis depresses immune function and may induce cancer. An ideal anti-cancer agent would inhibit prostaglandins in such a manner as to shut down the pathogenesis of cancer. In this paper, I will show that antidepressants have such properties.
摘要
前列腺素是转瞬即逝、极其微小的信号分子，它们自我调节身体中的每一个细胞，包括那些与情绪和免疫相关的细胞。起初，它们被视为一个主开关，但现在人们认为它们能调节细胞微观解剖学和生理学的各个组成部分，包括细胞器、细胞骨架、蛋白质、酶、核酸和线粒体的组成部分。矛盾的是，前列腺素既负责细胞的正常功能，也会导致细胞功能紊乱。前列腺素合成过多会抑制免疫功能，并可能诱发癌症。一种理想的抗癌药物应以能够阻断癌症发病机制的方式抑制前列腺素。在本文中，我将证明抗抑郁药具有这样的特性。
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