血清学和鼓室积液聚合酶链反应检测儿童特发性感觉神经性聋的病毒感染。

Viral infections detected by serology and PCR of perilymphatic fluid in children with idiopathic sensorineural hearing loss.

机构信息

Paediatric Infectious Diseases Research Centre, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

出版信息

East Mediterr Health J. 2011 Nov;17(11):867-70.

PMID:22276496

Abstract

The etiology of sensorineural hearing loss (SNHL) in children may be viral. This cross-sectional study aimed to determine the role of viral infectious agents in children with idiopathic SNHL. Of 119 children with SNHL aged 3-168 months undergoing cochlear implant surgery at a hospital in Tehran, no cause could be established in 18 cases (15.1%). Cytomegalovirus (CMV) and herpes simplex virus (HSV) active infections (detected by DNA-PCR, confirmed by serology) were found in the perilymphatic fluid of 16.7% (3/18) cases of idiopathic SNHL. Serology was performed on blood samples from 11 of these cases: specific antibodies against CMV, Toxoplasma spp., HSV and rubella were determined in all cases; acute T. gondii infection was detected in 7 cases and rubella IgG was found in only 1 case. Neonatal screening for CMV, HSV and T gondii may be helpful in the Islamic Republi of Iran.

摘要

儿童感音神经性听力损失（SNHL）的病因可能是病毒。本横断面研究旨在确定病毒感染因子在特发性 SNHL 儿童中的作用。在德黑兰一家医院接受耳蜗植入手术的 119 名 3-168 月龄的 SNHL 儿童中，18 例（15.1%）无法确定病因。在 18 例特发性 SNHL 中，有 16.7%（3/18）的病例发现了细胞巨化病毒（CMV）和单纯疱疹病毒（HSV）的活动性感染（通过 DNA-PCR 检测，通过血清学证实）。对其中 11 例进行了血清学检查：对所有病例均检测了针对 CMV、弓形体病、HSV 和风疹的特异性抗体；在 7 例中检测到急性弓形体病感染，仅在 1 例中发现风疹 IgG。在伊朗伊斯兰共和国，对 CMV、HSV 和 T 弓形体病进行新生儿筛查可能会有所帮助。