Dave Vivek P, Kaul Deepak, Sharma Monika
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research Chandigarh, 160 012, India.
Indian J Exp Biol. 2012 Jan;50(1):35-40.
An accumulation of data from in vitro to in vivo model system has established a pivotal role of three crucial ligand activated nuclear receptors RXR, LXR-alpha and VDR for their ability to regulate an array of genes involved in regulation of fundamental cellular processes to patho-physiological situations. Keeping in view RXR as a common heterodimeric partner for LXR-alpha and VDR, the present study was designed to dissect the interrelationship between these three nuclear receptors in peripheral blood mononuclear cellular model. The present study revealed that all the three nuclear receptors displayed auto regulation in response to their specific ligands; Both LXR-alpha and VDR regulated the expression of their heterodimeric partner RXR; and VDR was regulated by LXR-alpha through its ability to modulate SREBP response element present in the promoter region of VDR gene. Based on these findings, the role of these nuclear receptors could be better understood in various nuclear receptor mediated pathological processes.
从体外模型系统到体内模型系统积累的数据表明，三种关键的配体激活核受体RXR、LXR-α和VDR具有关键作用，因为它们能够调节一系列涉及从基本细胞过程到病理生理状况调控的基因。鉴于RXR是LXR-α和VDR的共同异二聚体伙伴，本研究旨在剖析外周血单核细胞模型中这三种核受体之间的相互关系。本研究表明，所有这三种核受体在响应其特定配体时均表现出自我调节；LXR-α和VDR均调节其异二聚体伙伴RXR的表达；并且VDR受LXR-α调节，因为LXR-α能够调节VDR基因启动子区域中存在的SREBP反应元件。基于这些发现，可以更好地理解这些核受体在各种核受体介导的病理过程中的作用。
