Subramanian Sarada, John Mathew
Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560 029, India.
Indian J Exp Biol. 2012 Jan;50(1):41-4.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal accumulation of amyloid beta (A beta) peptide in brain regions subserving memory and other cognitive functions. Hyperglycemia and perturbed insulin signaling have been proposed as pathogenic factors contributing to AD. The aim of the present study is to validate the use of streptozotocin (STZ) injected rats as an experimental model of AD. Using this model, the effect of intranasal administration of insulin on reduction of A beta levels was measured. The current findings strengthen the case for insulin as therapy for AD afflicted individuals with or without diabetes.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是在负责记忆和其他认知功能的脑区中淀粉样β（Aβ）肽异常积累。高血糖和胰岛素信号紊乱被认为是导致AD的致病因素。本研究的目的是验证链脲佐菌素（STZ）注射大鼠作为AD实验模型的有效性。利用该模型，测量了鼻内给予胰岛素对降低Aβ水平的作用。目前的研究结果进一步证明，胰岛素可用于治疗患有或未患有糖尿病的AD患者。
