Department of Clinical Science, Intervention and Technology, Division of Otorhinolaryngology, Karolinska Institutet, Stockholm, Sweden.
Otolaryngol Head Neck Surg. 2012 May;146(5):834-41. doi: 10.1177/0194599811435638. Epub 2012 Jan 27.
Nasal polyposis is a disease known to be associated with asthma. The long-term effects of surgical treatment on lower airways have not been sufficiently studied.
One-year follow-up of a double-blind, randomized, placebo-controlled study.
The study was conducted at the Karolinska University Hospital, Stockholm, Sweden.
Fifty-one patients, age 18 years or older, with nasal polyposis and asthma were evaluated 1 year after endoscopic sinus surgery (ESS). Outcomes included dyspnea/cough scores, mean daily peak expiratory flow rate, spirometry, butanol test, olfaction scores, peak nasal inspiratory flow, polyp scores, and health-related quality of life (SF-36).
The short-term postsurgery improvements in asthma symptom scores, daily peak expiratory flow rate, all nasal parameters including olfaction, and quality-of-life scores were generally maintained 1 year after ESS.
Endoscopic sinus surgery had beneficial long-term effects on asthma, olfaction, and quality of life in patients with nasal polyposis. This is the first study to show long-term benefits of ESS on butanol tests in patients with nasal polyposis.
鼻息肉是一种已知与哮喘相关的疾病。手术治疗对下呼吸道的长期影响尚未得到充分研究。
一项双盲、随机、安慰剂对照研究的 1 年随访。
研究在瑞典斯德哥尔摩卡罗林斯卡大学医院进行。
51 名年龄在 18 岁或以上、患有鼻息肉和哮喘的患者在接受内镜鼻窦手术（ESS）后 1 年进行评估。结果包括呼吸困难/咳嗽评分、平均每日峰值呼气流量、肺活量测定、丁醇试验、嗅觉评分、峰值鼻吸气流量、息肉评分和健康相关生活质量（SF-36）。
哮喘症状评分、每日峰值呼气流量、所有包括嗅觉在内的鼻部参数以及生活质量评分在 ESS 后短期内的改善通常在 1 年后仍能维持。
ESS 对鼻息肉患者的哮喘、嗅觉和生活质量具有长期有益的影响。这是第一项显示 ESS 对鼻息肉患者丁醇试验长期益处的研究。
