[先天性心脏病患儿血清脑钠肽水平与左心功能的相关性]

[Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease].

作者信息

Zhang He, Li Jiu-Jun

机构信息

Pediatric Intensive Care Unit, China Medical University, Shengjing Hospital, Shenyang 110004, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2012 Jan;14(1):42-4.

PMID:22289751

Abstract

OBJECTIVE

To study the correlation between the blood serum brain natriuretic peptide (BNP) level and the left cardiac function in children with congenital heart disease (CHD).

METHODS

The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure (CHF): CHD+CHF (n=21) and CHD alone (n=20). The blood serum BNP level was determined using chemiluminescence immunoassay, and the left ventricular ejection fraction (LVEF) was measured with echocardiogram.

RESULTS

The serum BNP level was 1353 pg/mL (range: 926-2978) in the CHD+CHF group, which was significantly higher than in the CHD alone group[149 pg/mL (range: 75-242)] (P<0.01). The LVEF was 60% (range: 53%-65%) in the CHD+CHF group, which was significantly lower than in the CHD alone group[68% (range: 64%-72%)] (P<0.01). The serum BNP level showed a negative correlation with the LVEF level (r=-0.652, P<0.01).

CONCLUSIONS

The blood serum BNP level is related to the cardiac function. For children with severe CHD+CHF, serum BNP level can be used as a sensitive indicator for evaluating cardiac function damage.

摘要

目的

研究先天性心脏病（CHD）患儿血清脑钠肽（BNP）水平与左心功能的相关性。

方法

回顾性分析41例CHD患儿的临床资料。根据是否存在充血性心力衰竭（CHF）将患者分为两组：CHD+CHF组（n=21）和单纯CHD组（n=20）。采用化学发光免疫分析法测定血清BNP水平，用超声心动图测量左心室射血分数（LVEF）。

结果

CHD+CHF组血清BNP水平为1353 pg/mL（范围：926 - 2978），显著高于单纯CHD组[149 pg/mL（范围：75 - 242）]（P<0.01）。CHD+CHF组LVEF为60%（范围：53% - 65%），显著低于单纯CHD组[68%（范围：64% - 72%）]（P<0.01）。血清BNP水平与LVEF水平呈负相关（r=-0.652，P<0.01）。