Selcuklu Faculty of Medicine, Selcuk University, Konya, Turkey.
J Ocul Pharmacol Ther. 2012 Jun;28(3):278-82. doi: 10.1089/jop.2011.0132. Epub 2012 Feb 3.
To evaluate posterior and anterior segment safety of an intracameral injection of moxifloxacin as prophylaxis for endophthalmitis in cataract surgery.
In this study, 60 eyes of 60 patients were included. In the first group, only 5% povidine iodine drop was administrated to 30 patients at the end of the surgery, while 30 patients were treated with intracameral moxifloxacin (250 μg/0.050 mL) additionally in the second group. Visual acuity, intraocular pressure, corneal pachymetry, corneal clarity, and edema and retinal thickness were evaluated preoperatively and for day 3 postoperatively for each group and were compared.
Mean preoperative visual acuity was 0.7 ± 0.9 LogMAR in both groups 1 and 2, while mean postoperative visual acuity was 0.05 ± 1.00 LogMAR in both groups. Preoperative and postoperative intraocular pressure averaged 13.2 ± 2.0 and 13.2 ± 2.1 mmHg, respectively, in the first group, while preoperative and postoperative intraocular pressure was 14.9 ± 2.1 and 14.3 ± 2.0, respectively, in the second group. Preoperative and postoperative visual acuity changes and intraocular pressure changes were not significantly different between 2 groups. There was no single case of corneal edema. In the first group, preoperative pachymetry was 523 ± 44 and postoperative pachmetry was 536 ± 45 μm, while in the second group preoperative pachymetry was 527 ± 43 and postoperative pachymetry was 543 ± 42 μm. Preoperative and postoperative pachymetry changes were not significantly different between 2 groups. Mean preoperative macular thickness in the first group was 188 ± 7.73 μm, while it was measured as 189 ± 7.75 μm postoperatively. In the second group, mean preoperative macular thickness was 188 ± 8.89 μm, while it was 189 ± 9.61 μm postoperatively. Preoperative and postoperative optical coherence tomography (OCT) measure changes were not significantly different between the 2 groups. No study-related adverse events were noted.
There was no increased safety risk associated with a 250 μm/0.050 mL intracameral injection of moxifloxacin, which appears to be safe in the prophylaxis of endophthalmitis after cataract surgery.
评估白内障手术中预防性应用莫西沙星眼内注射的眼前段和后段安全性。
本研究共纳入 60 例（60 只眼）患者。第 1 组 30 例手术结束时仅给予 5%聚维酮碘滴眼，第 2 组 30 例在此基础上给予莫西沙星（250μg/0.050mL）眼内注射。分别于术前和术后第 3 天对两组患者的视力、眼压、角膜厚度、角膜混浊、水肿和视网膜厚度进行评估，并进行比较。
两组患者术前平均视力均为 0.7±0.9 LogMAR，术后均为 0.05±1.00 LogMAR。第 1 组患者术前眼压平均为 13.2±2.0mmHg，术后为 13.2±2.1mmHg，第 2 组患者术前眼压平均为 14.9±2.1mmHg，术后为 14.3±2.0mmHg。两组间术前、术后视力变化和眼压变化差异均无统计学意义。两组均无角膜水肿病例。第 1 组患者术前角膜厚度为 523±44μm，术后为 536±45μm，第 2 组患者术前角膜厚度为 527±43μm，术后为 543±42μm。两组间术前、术后角膜厚度变化差异均无统计学意义。第 1 组患者术前黄斑厚度平均为 188±7.73μm，术后为 189±7.75μm，第 2 组患者术前黄斑厚度平均为 188±8.89μm，术后为 189±9.61μm。两组间术前、术后光学相干断层扫描（OCT）测量值变化差异均无统计学意义。未观察到与研究相关的不良事件。
250μg/0.050mL 莫西沙星眼内注射用于白内障手术后眼内炎预防未见安全性风险增加，安全性良好。
