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2
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本文引用的文献

1
Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.拓扑异构酶 1 和单链断裂修复调节人类细胞中转录诱导的 CAG 重复收缩。
Mol Cell Biol. 2011 Aug;31(15):3105-12. doi: 10.1128/MCB.05158-11. Epub 2011 May 31.
2
Mapping and analysis of chromatin state dynamics in nine human cell types.绘制和分析九种人类细胞类型中的染色质状态动态。
Nature. 2011 May 5;473(7345):43-9. doi: 10.1038/nature09906. Epub 2011 Mar 23.
3
The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).激酶抑制剂 TKI258 对在一名患有 T 淋巴细胞白血病/淋巴瘤和 t(7;8)(q22;p11)的患者中检测到的新型 CUX1-FGFR1 融合具有活性。
Haematologica. 2011 Jun;96(6):922-6. doi: 10.3324/haematol.2010.036558. Epub 2011 Feb 17.
4
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.激活诱导的胞嘧啶脱氨酶在活化 B 细胞中的许多非免疫球蛋白基因座诱导可重复的 DNA 断裂。
Mol Cell. 2011 Jan 21;41(2):232-42. doi: 10.1016/j.molcel.2011.01.007.
5
Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.拓扑异构酶 1 在酿酒酵母高转录时引发重复序列形成短缺失。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):692-7. doi: 10.1073/pnas.1012582108. Epub 2010 Dec 21.
6
Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.拓扑异构酶 1 在酵母转录相关诱变中的作用。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):698-703. doi: 10.1073/pnas.1012363108. Epub 2010 Dec 21.
7
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.组蛋白 3 赖氨酸 4 三甲基化受促进染色质转录复合物的调节，对于类别转换重组中的 DNA 切割至关重要。
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22190-5. doi: 10.1073/pnas.1016923108. Epub 2010 Dec 7.
8
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.在 B 淋巴细胞中，通过深度测序鉴定胞嘧啶脱氨酶 AID 及其辅助因子 RPA 的基因组靶标。
Nat Immunol. 2011 Jan;12(1):62-9. doi: 10.1038/ni.1964. Epub 2010 Nov 28.
9
Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis.人 T 细胞白血病病毒 Tax 癌蛋白对 AID 的激活作用及其在 ATL 发生中的可能作用。
Carcinogenesis. 2011 Jan;32(1):110-9. doi: 10.1093/carcin/bgq222. Epub 2010 Oct 25.
10
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.激活诱导的胞苷脱氨酶通过与Spt5相互作用，靶向RNA聚合酶II停滞位点的DNA。
Cell. 2010 Oct 1;143(1):122-33. doi: 10.1016/j.cell.2010.09.017.

激活诱导的胞嘧啶脱氨酶（AID）的非免疫球蛋白靶标与免疫球蛋白基因具有独特的特征。

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.

机构信息

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

出版信息

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2479-84. doi: 10.1073/pnas.1120791109. Epub 2012 Jan 30.

DOI:10.1073/pnas.1120791109
PMID:22308462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3289292/
Abstract

Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A, and CUX1) and confirmed that these loci accumulated mutations as frequently as Ig locus after AID activation. Moreover, these genes share three important characteristics with the Ig gene: translocations in tumors, repetitive sequences, and the epigenetic modification of chromatin by H3K4 trimethylation in the vicinity of cleavage sites.

摘要

激活诱导胞嘧啶脱氨酶（AID）是激活 B 细胞中体细胞超突变和类别转换重组所必需的。AID 也已知靶向非免疫球蛋白基因并引入突变或染色体易位，最终导致肿瘤。为了鉴定迄今为止未知的 AID 靶标，我们使用两种独立的全基因组方法筛选了早期 AID 诱导的 DNA 断裂。除了已知的 AID 靶标外，该筛选还鉴定了一组独特的基因（SNHG3、MALAT1、BCL7A 和 CUX1），并证实这些基因座在 AID 激活后与 Ig 基因一样频繁地积累突变。此外，这些基因与 Ig 基因具有三个重要特征：肿瘤中的易位、重复序列以及邻近切割位点处组蛋白 H3K4 三甲基化的染色质的表观遗传修饰。