治疗初治 HIV-1 感染成人的生殖器支原体和沙眼衣原体感染。

Genital mycoplasma & Chlamydia trachomatis infections in treatment naïve HIV-1 infected adults.

机构信息

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Med Res. 2011 Dec;134(6):960-6. doi: 10.4103/0971-5916.92643.

DOI:10.4103/0971-5916.92643

PMID:22310829

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3284105/

Abstract

BACKGROUND & OBJECTIVES: Sexually transmitted infections (STIs) enhance the transmission of human immunodeficiency virus (HIV). Thus, screening for STIs is a routine component of primary HIV care. There are limited data for selective screening guidelines for genital mycoplasmas and Chlamydia trachomatis in HIV-infected adults. The aim of the present study was to determine the frequency of genital infections with Ureaplasma spp., Mycoplasma hominis, M. genitalium and C. trachomatis in treatment naïve asymptomatic HIV-1 - infected adults and study their association with CD4+ T-cell count.

METHODS

First-void urine samples were collected from 100 treatment-naïve HIV-1-infected adults and 50 healthy volunteers. C. trachomatis and M. genitalium were detected by polymerase chain reaction (PCR). Ureaplasma spp. and M. hominis were detected by both culture and PCR. Circulating CD4+ cell counts of HIV-1-infected patients were determined from peripheral blood by flow-cytometry.

RESULTS

C. trachomatis was detected in 7 per cent of HIV-1-infected adults compared to none in control population. Ureaplasma spp. and M. hominis showed infection rates of 6 and 1 per cent in the HIV group and 2 and 0 per cent in the control group, respectively. None of the individuals from the patient and control groups was tested positive for M. genitalium. A significant association was found between CD4 cell count and detection of C. trachomatis in HIV-infected adults (P = 0.01).

INTERPRETATION & CONCLUSIONS: Screening of HIV-infected individuals for C. trachomatis infection could be recommended as a routine component of HIV care. The role of mycoplasmas as co-pathogens of the genitourinary tract in HIV-1 infected patients seems to be unlikely. Further longitudinal studies need to be done to confirm these findings.

摘要

背景与目的

性传播感染（STI）会增加人类免疫缺陷病毒（HIV）的传播。因此，筛查 STI 是 HIV 初级护理的常规组成部分。在感染 HIV 的成年人中，针对生殖器支原体和沙眼衣原体的选择性筛查指南的数据有限。本研究旨在确定未接受治疗的无症状 HIV-1 感染成年人中生殖器感染解脲脲原体、人型支原体、生殖支原体和沙眼衣原体的频率，并研究其与 CD4+ T 细胞计数的关系。

方法

采集 100 名未经治疗的 HIV-1 感染成年人和 50 名健康志愿者的首次尿液样本。通过聚合酶链反应（PCR）检测沙眼衣原体和生殖支原体。通过培养和 PCR 检测解脲脲原体和人型支原体。通过流式细胞术从外周血中确定 HIV-1 感染患者的循环 CD4+细胞计数。

结果

与对照组相比，7%的 HIV-1 感染成年人检测出沙眼衣原体，而对照组均未检测出。解脲脲原体和人型支原体在 HIV 组的感染率分别为 6%和 1%，在对照组分别为 2%和 0%。患者和对照组均未检测出生殖支原体。在 HIV 感染成年人中，CD4 细胞计数与沙眼衣原体检测之间存在显著相关性（P=0.01）。