[粉尘螨滴剂舌下免疫治疗对变应性鼻炎患者的疗效]

[Efficacy of sublingual immunotherapy with dermatophagoides farinae drops in patients with allergic rhinitis].

作者信息

Li Tian-ying, Chen De-hua, Lin Zhi-bin, Xu Rui

机构信息

Department of Otorhinolaryngology, First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Oct;46(10):859-62.

PMID:22321427

Abstract

OBJECTIVE

To evaluate the efficacy of sublingual immunotherapy (SLIT) with dermatophagoides farinae drops in patients with allergic rhinitis (AR).

METHODS

Two hundred and six patients with AR aged from 4 to 60 years were included in this study. Among them, 123 patients completed more than one year treatment, the number of patients completed one year, one year and a half, two years were 61, 41, 21 cases. Rhinitis symptom scores and medication scores of the three groups before and after treatment were compared. And rhinitis symptom scores and medication scores of patients with one year drug withdrawal after one and two years treatment were aslo compared.

RESULTS

After SLIT one year, one year and a half, two years treatment, the symptoms in these patients were significantly improved compared with before. The symptom scores (x±s) were reduced from 6.00±2.27, 7.39±1.99 and 6.29±2.14 to 2.95±1.82, 3.28±2.58, 2.48±1.99. The differences were statistically significant (t value was 8.19, 10.29, and 5.97, all P<0.01). The proportion of patients without drug treatment of the three group were 68.9%, 73.2% and 80.9%, there was statistical significance before and after treatment in every group (value was 50.391, 43.619, 27.776, all P<0.01). Symptom improvement of sneezing, runny nose, nasal congestion, nasal itching were similar after one year, one year and a half, two years SLIT treatment, the differences were not statistically significant (F values were 1.200, 1.276 and 2.333, all P>0.05). The proportion of patients without drug treatment in the group which stopped medication one year after two year SLIT (76.2%) was higher than group stopped medication one year after one year SLIT (61.3%). There was no statistical significance (χ2=1.263, P>0.05).

CONCLUSION

The dust mite drops can relieve symptoms after one year treatment, but the proposed two years treatment is important for the consolidation of improved symptoms, especially for the effect of reducing the use of symptomatic medication.

摘要

目的

评估舌下含服粉尘螨滴剂免疫疗法（SLIT）治疗变应性鼻炎（AR）患者的疗效。

方法

本研究纳入206例年龄在4至60岁的AR患者。其中，123例患者完成了一年以上的治疗，完成一年、一年半、两年治疗的患者人数分别为61例、41例、21例。比较三组治疗前后的鼻炎症状评分和用药评分。并比较治疗一年和两年后停药一年患者的鼻炎症状评分和用药评分。

结果

经过SLIT一年、一年半、两年治疗后，这些患者的症状较治疗前有显著改善。症状评分（x±s）从6.00±2.27、7.39±1.99和6.29±2.14降至2.95±1.82、3.28±2.58、2.48±1.99。差异具有统计学意义（t值分别为8.19、10.29和5.97，均P<0.01）。三组未用药患者的比例分别为68.9%、73.2%和80.9%，每组治疗前后差异均有统计学意义（值分别为50.391、43.619、27.776，均P<0.01）。经过SLIT一年、一年半、两年治疗后，打喷嚏、流涕、鼻塞、鼻痒症状的改善情况相似，差异无统计学意义（F值分别为1.200、1.276和2.333，均P>0.05）。两年SLIT治疗后停药一年组（76.2%）未用药患者的比例高于一年SLIT治疗后停药一年组（61.3%）。差异无统计学意义（χ2=1.263，P>0.05）。