人表皮生长因子（hEGF）对犬内脏循环的影响。

Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs.

作者信息

Sumi S, Inoue K, Hosotani R, Kogire M, Doi R, Yun M, Higashide S, Minote H, Takaori K, Kaji H

机构信息

First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.

出版信息

Life Sci. 1990;47(13):1115-9. doi: 10.1016/0024-3205(90)90170-v.

DOI:10.1016/0024-3205(90)90170-v

PMID:2233130

Abstract

The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4% at 1 microgram/kg) and the superior mesenteric artery (49.0 +/- 16.8% at 1 microgram/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4 +/- 1.2% at 1 microgram/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.

摘要

在麻醉犬中，使用超声渡越时间体积流量计，研究了静脉注射人表皮生长因子对内脏血流的影响。人表皮生长因子（0.1、0.5和1微克/千克）显著增加门静脉血流（1微克/千克时增加36.9±7.4%）和肠系膜上动脉血流（1微克/千克时增加49.0±16.8%）。同时监测的全身血压显著降低（1微克/千克时降低8.4±1.2%）。本研究首次证明静脉注射表皮生长因子可增加门静脉血流。