[俄罗斯人群中DNA修复基因ERCC2和XRCC1的多态性]

[Polymorphisms of DNA repair genes ERCC2 and XRCC1 in populations of Russia].

作者信息

Khrunin A V, Firsov S Iu, Limborskaia S A

出版信息

Genetika. 2011 Nov;47(11):1565-8.

Abstract

We have conducted a comparative study of allele frequencies of single nucleotide polymorphisms (SNPs) rs1799793 and rs13181 of the ERCC2 gene as well as rs1799782 and rs25487 of the XRCC1 gene in population samples from European regions of Russia as well as in populations of Izhemsk and Priluzsk Komi and Yakuts. Significant differences in the distribution of polymorphic variants of the ERCC2 gene were demonstrated between populations of Yakuts and populations of Russians and Komi. In case of XRCC1 gene Izhemsk Komi population exhibited dissimilar allele frequencies compared to other populations.

摘要

我们对俄罗斯欧洲地区人群样本以及伊热姆、普里卢茨克科米和雅库特人群中ERCC2基因的单核苷酸多态性（SNP）rs1799793和rs13181以及XRCC1基因的rs1799782和rs25487的等位基因频率进行了比较研究。结果表明，雅库特人群与俄罗斯人和科米人群之间，ERCC2基因多态性变体的分布存在显著差异。就XRCC1基因而言，伊热姆科米人群与其他人群相比，等位基因频率有所不同。