Lachnit V
Wien Klin Wochenschr. 1979 Jun 22;91(13):435-41.
The early diagnosis of lead poisoning -- the most common type of occupational metal poisoning -- based on the determination of the haemprecursors coproporphyrin, delta amino laevulinic acid and free erythrocyte protoporphyrin. Treatment with chelating agents increases urinary lead excretion very effectively. Clinical manifestations of mercury poisoning are different with organic and inorganic mercury compounds. Cadmium poisoning results in inhibition of non-specific enzymes. Depending on the mode of exposure, alteration of the epithelium of the renal tubules or skeletal damage is seen. The toxic effects of chromium are primarily due to direct contact and absorption. Chromium is also carcinogenic. The importance of technical prophylaxis is stressed.
铅中毒是最常见的职业性金属中毒类型，其早期诊断基于对血卟啉前体粪卟啉、δ-氨基乙酰丙酸和游离红细胞原卟啉的测定。螯合剂治疗能非常有效地增加尿铅排泄。汞中毒的临床表现因有机汞化合物和无机汞化合物而异。镉中毒会导致非特异性酶的抑制。根据接触方式的不同，可观察到肾小管上皮的改变或骨骼损伤。铬的毒性作用主要是由于直接接触和吸收。铬也是致癌物质。强调了技术预防的重要性。
