TRADD 在死亡受体信号转导中的作用。
The role of TRADD in death receptor signaling.
机构信息
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Cell Cycle. 2012 Mar 1;11(5):871-6. doi: 10.4161/cc.11.5.19300.
Abstract
TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor receptor 1). TNFR1 belongs to the so-called death receptor (DR) family of receptors that depending on the context can induce either apoptosis or proliferation, as well as NF-κB and MAP kinase activation. The receptors of this group contain death domain (DD) that is necessary for the induction of apoptosis. This review summarizes the recent advances in the field of DR signaling and in particular the role of TRADD.
摘要
TRADD（肿瘤坏死因子受体 1 相关死亡结构域蛋白）最初被鉴定为一种衔接分子，可将 TNFR1（肿瘤坏死因子受体 1）下游的信号转导。TNFR1 属于所谓的死亡受体（DR）家族受体，根据具体情况可以诱导凋亡或增殖，以及 NF-κB 和 MAP 激酶的激活。该组受体含有死亡结构域（DD），这是诱导凋亡所必需的。本综述总结了 DR 信号转导领域的最新进展，特别是 TRADD 的作用。
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