老年患者新型隐球菌性骨髓炎。病例报告及文献复习。

Osteomyelitis due to Cryptococcus neoformans in advanced age. Case report and review of literature.

作者信息

Kromminga R, Staib F, Thalmann U, Jautzke G, Seibold M, Hochrein H, Witt H, Bürger H

机构信息

Pathological Institute, Rudolf Virchow University Hospital, Wedding, Berlin, Germany FR.

出版信息

Mycoses. 1990 Apr;33(4):157-66. doi: 10.1111/myc.1990.33.4.157.

DOI:10.1111/myc.1990.33.4.157

PMID:2233890

Abstract

In an 84-year-old man cryptococcosis with a pronounced osteomyelitic course (involvement of a rib, two thoracic vertebrae, the sacrum and a femur) was diagnosed histologically post mortem, thus directing attention to cryptococcosis in advanced age. The presumptive chronic course of the Cryptococcus neoformans (Cr. n.) infection in this patient was ascribed to chronic kidney failure, diabetes mellitus and chronic obstructive lung disease. Special reference is made to the mycological and radiological diagnosis of cryptococcosis of the bones as well as to its pathogenesis, therapy and epidemiology.

摘要

一名84岁男性患者，尸检时经组织学诊断为隐球菌病，病程呈明显的骨髓炎表现（累及一根肋骨、两节胸椎、骶骨和一根股骨），从而使人们关注老年患者的隐球菌病。该患者新型隐球菌感染的推测慢性病程归因于慢性肾衰竭、糖尿病和慢性阻塞性肺疾病。特别提及了骨隐球菌病的真菌学和放射学诊断及其发病机制、治疗和流行病学。