Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg. 2012 Jun;143(6):1404-10. doi: 10.1016/j.jtcvs.2012.01.069. Epub 2012 Feb 17.
Cardiac catheterization shortly before coronary artery bypass grafting or valve surgery has been associated with increased postoperative acute kidney injury. The relationship between catheterization timing and acute kidney injury after proximal aortic surgery remains unknown.
Between August 2005 and February 2011, a total of 285 consecutive patients underwent cardiac catheterization before elective proximal aortic surgery with cardiopulmonary bypass at a single institution. The association between timing of catheterization and postoperative acute kidney injury (defined as postoperative increase in serum creatinine ≥ 50% of baseline) was assessed using logistic regression analysis.
Of 285 patients, 152 (53%) underwent catheterization on preoperative days 1 to 3 and 133 (47%) underwent catheterization on preoperative day 4 or before. Acute kidney injury occurred in 88 (31%) patients, 3 (1.1%) requiring dialysis. Acute kidney injury occurred in 37 (24%) patients catheterized on preoperative days 1 to 3, and 51 (38%) patients catheterized on preoperative day 4 or before. Catheterization on preoperative days 1 to 3 was not associated with an increased risk of acute kidney injury relative to catheterization on preoperative day 4 or before (unadjusted odds ratio, 0.52; 95% confidence interval, 0.31-0.86; P = .01; adjusted odds ratio, 0.35; 95% confidence interval, 0.17-0.73; P = .005).
Cardiac catheterization within 1 to 3 days of elective proximal aortic surgery appears safe and should be considered acceptable practice for patients at low risk of acute kidney injury.
在冠状动脉旁路移植术或瓣膜手术前进行心脏导管检查与术后急性肾损伤增加有关。经升主动脉手术前导管插入术时间与急性肾损伤之间的关系尚不清楚。
在 2005 年 8 月至 2011 年 2 月期间,一家机构共有 285 名连续接受择期经升主动脉手术并进行体外循环的患者在手术前行心脏导管检查。使用逻辑回归分析评估导管插入术时机与术后急性肾损伤(定义为术后血清肌酐增加≥基线的 50%)之间的关系。
在 285 名患者中,152 名(53%)在术前 1 至 3 天进行了导管检查,133 名(47%)在术前第 4 天或之前进行了导管检查。88 名(31%)接受术前 1 至 3 天导管检查的患者发生急性肾损伤,3 名(1.1%)需要透析。术前 1 至 3 天接受导管检查的患者中有 37 名(24%)发生急性肾损伤,而术前第 4 天或之前接受导管检查的患者中有 51 名(38%)发生急性肾损伤。与术前第 4 天或之前相比,术前 1 至 3 天的导管检查与急性肾损伤的风险增加无关(未调整的优势比,0.52;95%置信区间,0.31-0.86;P=0.01;调整后的优势比,0.35;95%置信区间,0.17-0.73;P=0.005)。
在择期经升主动脉手术前 1 至 3 天内进行心脏导管检查似乎是安全的,对于急性肾损伤风险较低的患者,应考虑可接受的做法。