阵发性夜间血红蛋白尿发病机制的新观点：由于黏附缺陷、迁移增强以及对红细胞释放的1-磷酸鞘氨醇梯度的动员反应，更具运动性的阵发性夜间血红蛋白尿造血干/祖细胞将正常造血干细胞从骨髓龛位中置换出来。 - Suppr

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A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.

作者信息

Ratajczak J, Kucia M, Mierzejewska K, Liu R, Kim C H, Natarajan N, Sharma V, Miller D M, Maciejewski J, Ratajczak M Z

出版信息

Leukemia. 2012 Jul;26(7):1722-5. doi: 10.1038/leu.2012.46. Epub 2012 Feb 20.

DOI:10.1038/leu.2012.46

PMID:22343521

Abstract

摘要

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A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.

作者信息

Ratajczak J, Kucia M, Mierzejewska K, Liu R, Kim C H, Natarajan N, Sharma V, Miller D M, Maciejewski J, Ratajczak M Z

出版信息

Leukemia. 2012 Jul;26(7):1722-5. doi: 10.1038/leu.2012.46. Epub 2012 Feb 20.

DOI:10.1038/leu.2012.46

PMID:22343521

Abstract

摘要