Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany.
Diabetes. 2012 Apr;61(4):782-9. doi: 10.2337/db11-1390. Epub 2012 Feb 16.
The role of brain insulin signaling in the control of food intake in humans has not been thoroughly defined. We hypothesized that the hormone contributes to the postprandial regulation of appetite for palatable food, and assessed the effects on appetite and snack intake of postprandial versus fasted intranasal insulin administration to the brain in healthy women. Two groups of subjects were intranasally administered 160 IU insulin or vehicle after lunch. Two hours later, consumption of cookies of varying palatability was measured under the pretext of a taste test. In a control study, the effects of intranasal insulin administered to fasted female subjects were assessed. Compared with placebo, insulin administration in the postprandial but not in the fasted state decreased appetite as well as intake and rated palatability of chocolate chip cookies (the most palatable snack offered). In both experiments, intranasal insulin induced a slight decrease in plasma glucose but did not affect serum insulin concentrations. Data indicate that brain insulin acts as a relevant satiety signal during the postprandial period, in particular reducing the intake of highly palatable food, and impacts peripheral glucose homeostasis. Postprandial intranasal insulin administration might be useful in curtailing overconsumption of snacks with accentuated rewarding value.
大脑胰岛素信号在人类食物摄入控制中的作用尚未得到充分定义。我们假设该激素有助于餐后美味食物的食欲调节，并评估了在健康女性中，餐后与空腹经鼻内给予大脑胰岛素对食欲和零食摄入的影响。两组受试者在午餐后分别经鼻内给予 160IU 胰岛素或载体。两小时后，以味觉测试为借口测量不同美味程度曲奇的摄入量。在一项对照研究中，评估了空腹女性受试者经鼻内给予胰岛素的影响。与安慰剂相比，餐后而非空腹时给予胰岛素可降低食欲以及巧克力曲奇（提供的最可口零食）的摄入量和评价美味程度。在这两项实验中，经鼻内给予胰岛素可轻微降低血糖，但不影响血清胰岛素浓度。数据表明，餐后大脑胰岛素作为一种相关的饱腹感信号发挥作用，特别是减少了对高美味食物的摄入，并影响外周葡萄糖稳态。餐后经鼻内给予胰岛素可能有助于减少具有明显奖励价值的零食过度摄入。
