一种分子光开关 Ru 配合物和量子点，用于无标记、基于适配体的凝血酶检测。

A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin.

机构信息

Department of Chemistry, Tongji University, Shanghai 200092, China.

出版信息

Analyst. 2012 Apr 7;137(7):1550-2. doi: 10.1039/c2an16181h. Epub 2012 Feb 21.

Abstract

A simple, label-free method for the detection of thrombin has been developed based on the conformational transition of aptamer in the presence of the target by using a molecular light switch, Ru polypyridine complex, and quantum dots as novel fluorescence probes in aqueous solution.

摘要

基于分子光开关、Ru 多吡啶配合物和量子点作为新型荧光探针在水溶液中，通过目标物存在时适体的构象转变，建立了一种简单、无需标记的凝血酶检测方法。