自身免疫产生中的次要受体编辑。
Secondary receptor editing in the generation of autoimmunity.
机构信息
Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104-6160, United States.
出版信息
Autoimmun Rev. 2012 Sep;11(11):787-9. doi: 10.1016/j.autrev.2012.02.004. Epub 2012 Feb 14.
Abstract
Receptor editing is the process that replaces the heavy chain or light chain variable region genes in a B cell immunoglobulin receptor that is already productively rearranged. It is a major mechanism in the bone marrow for maintaining B cell tolerance to autoantigens. We propose that a pathological autoimmune process can use receptor editing to induce the de novo creation and activation of B cells with autoreactive receptors in the peripheral immune system.
摘要
受体编辑是指在已经发生有效重排的 B 细胞免疫球蛋白受体中替换重链或轻链可变区基因的过程。它是骨髓中维持 B 细胞对自身抗原耐受的主要机制。我们提出，一种病理性自身免疫过程可以利用受体编辑在周围免疫系统中诱导具有自身反应性受体的 B 细胞的从头产生和激活。
相似文献
1
Secondary receptor editing in the generation of autoimmunity.自身免疫产生中的次要受体编辑。
Autoimmun Rev. 2012 Sep;11(11):787-9. doi: 10.1016/j.autrev.2012.02.004. Epub 2012 Feb 14.
2
The scope of receptor editing and its association with autoimmunity.受体编辑的范围及其与自身免疫的关联。
Curr Opin Immunol. 2004 Dec;16(6):808-14. doi: 10.1016/j.coi.2004.09.017.
3
Alternative mechanisms of receptor editing in autoreactive B cells.自身反应性 B 细胞中受体编辑的替代机制。
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7125-30. doi: 10.1073/pnas.1019389108. Epub 2011 Apr 6.
4
5
B-cell tolerance checkpoints in health and autoimmunity.健康与自身免疫中的B细胞耐受检查点。
Curr Opin Immunol. 2008 Dec;20(6):632-8. doi: 10.1016/j.coi.2008.09.001. Epub 2008 Oct 25.
6
Contribution of secondary Igkappa rearrangement to primary immunoglobulin repertoire diversification.继发性免疫球蛋白κ轻链重排对原发性免疫球蛋白库多样化的贡献。
Mol Immunol. 2016 Oct;78:193-206. doi: 10.1016/j.molimm.2016.09.006. Epub 2016 Sep 22.
7
Ig heavy-chain gene revision: leaping towards autoimmunity.免疫球蛋白重链基因重排：向自身免疫迈进。
Trends Immunol. 2001 Jul;22(7):400-5. doi: 10.1016/s1471-4906(01)01953-6.
8
Positive selection of low affinity autoreactive B cells.低亲和力自身反应性B细胞的阳性选择。
Curr Top Microbiol Immunol. 2000;252:39-45. doi: 10.1007/978-3-642-57284-5_5.
9
Receptor editing, immune diversification, and self-tolerance.受体编辑、免疫多样化与自身耐受性。
Immunity. 1996 Dec;5(6):505-11. doi: 10.1016/s1074-7613(00)80266-6.
10
B cell receptor editing in tolerance and autoimmunity.B 细胞受体编辑在免疫耐受和自身免疫中的作用。
Ann N Y Acad Sci. 2011 Jan;1217:96-121. doi: 10.1111/j.1749-6632.2010.05877.x. Epub 2011 Jan 5.
引用本文的文献
1
Trials and Tribulations with VH Replacement.VH 置换的试验与磨难
Front Immunol. 2014 Jan 30;5:10. doi: 10.3389/fimmu.2014.00010. eCollection 2014.
2
Cytokinergic IgE Action in Mast Cell Activation.细胞因子 IgE 作用于肥大细胞激活。
Front Immunol. 2012 Aug 6;3:229. doi: 10.3389/fimmu.2012.00229. eCollection 2012.
本文引用的文献
1
B cell receptor editing in tolerance and autoimmunity.B 细胞受体编辑在免疫耐受和自身免疫中的作用。
Ann N Y Acad Sci. 2011 Jan;1217:96-121. doi: 10.1111/j.1749-6632.2010.05877.x. Epub 2011 Jan 5.
2
Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.体突变作为系统性自身免疫小鼠模型中抗核抗体的产生机制。
J Exp Med. 2010 Sep 27;207(10):2225-37. doi: 10.1084/jem.20092712. Epub 2010 Aug 30.
3
Signaling pathways regulating RAG expression in B lymphocytes.调节B淋巴细胞中RAG表达的信号通路。
Autoimmun Rev. 2009 Jun;8(7):599-604. doi: 10.1016/j.autrev.2009.02.004. Epub 2009 Feb 9.
4
T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice.C57BL/6小鼠中抗双链DNA B细胞非T细胞依赖性的自发耐受性丧失。
J Immunol. 2008 Dec 1;181(11):7770-7. doi: 10.4049/jimmunol.181.11.7770.
5
B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice.B细胞受体修正可减少小鼠抗原激活后自身反应性B细胞的应答。
J Clin Invest. 2008 Aug;118(8):2896-907. doi: 10.1172/JCI35618.
6
RAG-mediated secondary rearrangements of B-cell antigen receptors in rheumatoid synovial tissue.类风湿性滑膜组织中RAG介导的B细胞抗原受体二次重排
Autoimmun Rev. 2007 Dec;7(2):155-9. doi: 10.1016/j.autrev.2007.02.011. Epub 2007 Mar 21.
7
Mature B cells preferentially lose tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus.在系统性红斑狼疮的慢性移植物抗宿主病模型中，成熟B细胞优先丧失耐受性。
J Immunol. 2007 Oct 15;179(8):5564-70. doi: 10.4049/jimmunol.179.8.5564.
8
Peripheral expression of RAG in human B lymphocytes in normal and pathological conditions is dependent on interleukin-6.在正常和病理条件下，人类B淋巴细胞中RAG的外周表达依赖于白细胞介素-6。
Autoimmun Rev. 2007 Jun;6(6):415-20. doi: 10.1016/j.autrev.2007.01.002. Epub 2007 Feb 2.
9
Central and peripheral RAG protein re-expression: underestimate mechanisms of tolerance?中枢和外周RAG蛋白重新表达：是否低估了耐受机制？
Scand J Immunol. 2006 Sep;64(3):185-9. doi: 10.1111/j.1365-3083.2006.01801.x.
10
Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens.受体编辑可导致等位基因包含以及保留与高亲和力自身抗原发生反应的抗体的B细胞的发育。
J Immunol. 2005 Oct 15;175(8):5067-76. doi: 10.4049/jimmunol.175.8.5067.
Zotero 插件