自身免疫产生中的次要受体编辑。
Secondary receptor editing in the generation of autoimmunity.
机构信息
Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104-6160, United States.
出版信息
Autoimmun Rev. 2012 Sep;11(11):787-9. doi: 10.1016/j.autrev.2012.02.004. Epub 2012 Feb 14.
Abstract
Receptor editing is the process that replaces the heavy chain or light chain variable region genes in a B cell immunoglobulin receptor that is already productively rearranged. It is a major mechanism in the bone marrow for maintaining B cell tolerance to autoantigens. We propose that a pathological autoimmune process can use receptor editing to induce the de novo creation and activation of B cells with autoreactive receptors in the peripheral immune system.
摘要
受体编辑是指在已经发生有效重排的 B 细胞免疫球蛋白受体中替换重链或轻链可变区基因的过程。它是骨髓中维持 B 细胞对自身抗原耐受的主要机制。我们提出，一种病理性自身免疫过程可以利用受体编辑在周围免疫系统中诱导具有自身反应性受体的 B 细胞的从头产生和激活。
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