School of Molecular and Systems Medicine, Alberta Diabetes Institute, University of Alberta, 6126 HRIF East, Edmonton AB T6G 2E1, Canada.
J Bioenerg Biomembr. 2012 Feb;44(1):199-205. doi: 10.1007/s10863-012-9407-6.
Recent advances in structural biology underlying mechanisms of channel gating have strengthened our knowledge about how K(+) channels can be inter-convertible between conductive and non-conductive states. We have reviewed and combined mutagenesis with biochemical, biophysical and structural information in order to understand the critical roles of the pore residues in stabilizing the pore structure and channel open state. We also discuss how the latest knowledge on the K(+) channel KcsA may provide a step towards better understanding of distinct pore stabilizing differences among diversified K(+) channels.
最近在通道门控机制的结构生物学方面的进展加强了我们对钾通道如何在传导和非传导状态之间相互转换的理解。我们综述了突变与生化、生物物理和结构信息相结合的研究，以了解孔残基在稳定孔结构和通道开放状态中的关键作用。我们还讨论了最新的钾通道 KcsA 知识如何为更好地理解多样化的钾通道中不同的孔稳定差异提供一个切入点。
