皮肤软斑病。迈-古二氏小体的超微结构及定量X射线微分析

Malakoplakia of the skin. Ultrastructure and quantitative x-ray microanalysis of Michaelis-Gutmann bodies.

作者信息

Sencer O, Sencer H, Uluoğlu O, Torunoğlu M, Tatlicioğlu E

出版信息

Arch Pathol Lab Med. 1979 Aug;103(9):446-50.

Abstract

The etiologic agent in a case of malakoplakia of the skin was identified as Staphylococcus aureus from culture of the lesion and from ultrastructural observations. Ultrastructurally, electron-dense inclusions were observed in addition to membranous whorls and Michaelis-Gutmann (MG) bodies. These were labeled "precalcification formations" since they possessed an organic crystalline structure. These formations may act as nucleation centers for further incorporation of organic and inorganic material. Deposition of fine crystalline material in the outer region may occur as the structure becomes saturated with inorganic elements, thus completing formation of the MG body. Quantitative x-ray microanalysis of MG bodies demonstrated the presence of phosphorus, calcium, and iron, with average concentrations of 2.1%, 2.6%, and 0.7% by weight, respectively.

摘要

通过对病变组织的培养和超微结构观察，确定一例皮肤软斑病的病原体为金黄色葡萄球菌。在超微结构上，除了膜性涡旋和米凯利斯-古特曼（MG）小体外，还观察到电子致密包涵体。由于它们具有有机晶体结构，这些被标记为“预钙化结构”。这些结构可能作为进一步结合有机和无机物质的成核中心。随着结构中无机元素饱和，可能会在外部区域发生细晶材料的沉积，从而完成MG小体的形成。对MG小体的定量X射线微分析表明存在磷、钙和铁，平均重量浓度分别为2.1%、2.6%和0.7%。