核蛋白酪氨酸磷酸酶 PLCβ1 与骨髓增生异常综合征：遗传学和表观遗传学。

Nuclear PI-PLCβ1 and myelodysplastic syndromes: genetics and epigenetics.

机构信息

Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy.

出版信息

Curr Pharm Des. 2012;18(13):1751-4. doi: 10.2174/138161212799859710.

Abstract

Among cellular second messengers inositides play key roles in signal transduction pathways. Indeed, nuclear phosphoinositide- specific phospholipase C (PI-PLC) β1 and Akt are involved in cell cycle progression and apoptosis. Nuclear lipid metabolism has raised interest in the last years, mainly because of its link with haematopoietic progenitor cells. Myelodysplastic syndromes (MDS) are stem-cell clonal diseases characterized by an impaired hempoiesis and a differentiation defect in one or more of the bone marrow lineages, often leading to progression to acute myeloid leukaemia (AML). The MDS evolution to AML is not completely understood but, at a molecular level, the nuclear inositide signalling pathways can play an important role in this process.

摘要

在细胞内的第二信使中，肌醇磷脂在信号转导途径中起着关键作用。事实上，核磷酰肌醇特异性磷脂酶 C（PI-PLC）β1 和 Akt 参与细胞周期进程和细胞凋亡。近年来，核脂代谢引起了人们的兴趣，主要是因为它与造血祖细胞有关。骨髓增生异常综合征（MDS）是一种干细胞克隆疾病，其特征是造血功能受损，骨髓谱系中的一个或多个谱系分化缺陷，常导致急性髓系白血病（AML）的进展。MDS 向 AML 的演变尚不完全清楚，但在分子水平上，核肌醇信号通路可能在这一过程中发挥重要作用。