MBL2 基因外显子 1 变异与巴西自身免疫性甲状腺疾病患者的关联。
Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.
机构信息
Internal Medicine's Unit of Otavio de Freitas's Hospital, Recife, Brazil.
出版信息
Int J Immunogenet. 2012 Aug;39(4):357-61. doi: 10.1111/j.1744-313X.2012.01102.x. Epub 2012 Feb 23.
We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.
我们研究了甘露聚糖结合凝集素 2 基因外显子 1 功能多态性与 163 例巴西患者（87 例桥本甲状腺炎，HT；76 例格雷夫斯病）和 214 例健康对照者自身免疫性甲状腺疾病（AITD）之间的关联。携带 MBL2 O 等位基因的个体发生 AITD（OR = 1.58，95%CI：1.11-2.26；P 值 = 0.009）和 HT（OR = 1.67，95%CI：1.09-2.55；P 值 = 0.013）的风险更高，这表明甘露聚糖结合凝集素可能在影响疾病易感性方面发挥作用。
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