Li Jin, Lan Zhi-gang, Liu Yi, He Min, You Chao
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang Street, Chengdu, Sichuan 610041, PR China.
Clin Neurol Neurosurg. 2012 Sep;114(7):907-13. doi: 10.1016/j.clineuro.2012.01.039. Epub 2012 Feb 22.
Surgical treatment of large and giant ventral paraclinoid carotid aneurysms (vPCAs) continues to be challenging and technically demanding for vascular neurosurgeons. Due to both physiological barriers and limitations of current surgical technology in the treatment of vPCAs, higher rates of morbidity and mortality are a given. To improve the current available data and assess the most effective microsurgical management techniques with the goal of decreased morbidity and mortality, we present this retrospective study of a series of 15 consecutive patients with large and giant vPCAs.
Between January 2005 and December 2010, fifteen patients presented with large or giant vPCAs were surgically treated at West China Hospital and were included in this study. The data was retrospectively analyzed.
Five men and ten women with an averaging 50 years of age (ranged 32-70 years) were included in this study. The average aneurysm size was 21 mm (ranged 13-36 mm). All patients were treated microsurgically. Twelve patients (80%) had desirable surgical outcomes (Glasgow Outcome Score 4-5) at follow-up for a mean of 32 months (range 3-72 months). One patient (7%) died of severe vasospasm after surgery. The surgical mortality was 7%; overall morbidity was 27%, including the hemiplegia, oculomotor paresis and visual deficit. None of the 14 following patients had rebleeding or regrowth of residual aneurysm during this follow-up period. Age and Hunt-Hess grade were significantly correlated with clinical outcome.
Despite the difficulties presented by large and giant vPCAs, our increased knowledge of anatomy and refinements in operative techniques and intraoperative monitoring have greatly improved the clinical outcome with a more acceptable mortality and morbidity.
对于血管神经外科医生而言,大型和巨大型海绵窦旁颈内动脉瘤(vPCA)的外科治疗仍然具有挑战性,技术要求也很高。由于在vPCA治疗中存在生理障碍和当前外科技术的局限性,较高的发病率和死亡率是必然的。为了完善现有数据,并评估最有效的显微外科治疗技术以降低发病率和死亡率,我们对连续15例大型和巨大型vPCA患者进行了这项回顾性研究。
2005年1月至2010年12月期间,15例患有大型或巨大型vPCA的患者在华西医院接受了手术治疗,并纳入本研究。对数据进行回顾性分析。
本研究纳入了5名男性和10名女性,平均年龄50岁(范围32 - 70岁)。动脉瘤平均大小为21mm(范围13 - 36mm)。所有患者均接受了显微手术治疗。12例患者(80%)在平均32个月(范围3 - 72个月)的随访中获得了理想的手术结果(格拉斯哥预后评分4 - 5分)。1例患者(7%)术后死于严重血管痉挛。手术死亡率为7%;总体发病率为27%,包括偏瘫、动眼神经麻痹和视力障碍。在该随访期内,14例随访患者均未出现再出血或残余动脉瘤复发。年龄和Hunt - Hess分级与临床结果显著相关。
尽管大型和巨大型vPCA带来了诸多困难,但我们对解剖结构的深入了解以及手术技术和术中监测的改进,已极大地改善了临床结果,使死亡率和发病率更易接受。