与白色念珠菌DNA相比，金黄色葡萄球菌DNA引起的尿路感染。
Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA.
作者信息
Al-Mathkhury Harith Jabbar Fahad, Abdul-Ghaffar Saba Nazeih
机构信息
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
出版信息
N Am J Med Sci. 2011 Dec;3(12):565-9. doi: 10.4297/najms.2011.3562.
BACKGROUND
Bacterial DNA released upon bacterial autolysis or killed by antibiotics, hence, many inflammatogenic reactions will be established leading to serious tissue damage.
AIM
the present work aimed to elucidate the histopathological changes caused by prokaryotic (bacterial) DNA and eukaryotic (candidal) DNA.
MATERIALS AND METHODS
twenty one Staphylococcus aureus and 36 Candida albicans isolates were isolated from UTI patients. Viable cells and DNA of the highest antibiotic sensitive isolates were injected, intraurethraly, in mice. Results were evaluated via histopathological examination.
RESULTS
Mildest reactions were obtained from mice challenged with viable C. albicans compared with those challenged with viable S. aureus. Dose-dependent histological changes were observed for both eukaryotic and prokaryotic DNA. However, the eukaryotic C. albicans DNA developed less intense histological changes than S. aureus DNA.
CONCLUSION
microbial DNA has the ability to cause damage in murine renal system. Nevertheless, bacterial DNA caused more intense damage than candidal DNA.
背景
细菌自溶或被抗生素杀死后释放出的细菌DNA，会引发许多致炎反应，导致严重的组织损伤。
目的
本研究旨在阐明原核（细菌）DNA和真核（念珠菌）DNA引起的组织病理学变化。
材料与方法
从尿路感染患者中分离出21株金黄色葡萄球菌和36株白色念珠菌。将对最高抗生素敏感性的分离株的活细胞和DNA经尿道注射到小鼠体内。通过组织病理学检查评估结果。
结果
与用活的金黄色葡萄球菌攻击的小鼠相比，用活的白色念珠菌攻击的小鼠产生的反应最轻微。真核和原核DNA均观察到剂量依赖性组织学变化。然而，真核白色念珠菌DNA产生的组织学变化比金黄色葡萄球菌DNA轻。
结论
微生物DNA有能力对小鼠肾脏系统造成损害。然而，细菌DNA造成的损害比念珠菌DNA更严重。
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