Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA.
Ophthalmology. 2012 Jun;119(6):1126-9. doi: 10.1016/j.ophtha.2011.12.037. Epub 2012 Feb 25.
To evaluate the long-term improvement of visual acuity after Descemet's stripping automated endothelial keratoplasty (DSAEK) surgery.
Retrospective analysis of a noncomparative, interventional case series.
One hundred eight patients undergoing DSAEK surgery for Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy without other ocular comorbidities who completed a full 3-year follow-up period.
Postoperative best spectacle-corrected visual acuity (BSCVA) was recorded at 6, 12, 24, and 36 months. Improvement in BSCVA between each time point was evaluated using paired-samples t tests. Subanalysis evaluating the percentage of eyes achieving a BSCVA of 20/20, 20/25, 20/30, and 20/40 at each time point was performed.
Improvement in postoperative BSCVA.
There was a statistically significant trend toward improvement in average BSCVA with time at postoperative month 6 and postoperative years 2 and 3. There were also increasing proportions of eyes reaching vision of 20/20, 20/25, and 20/30 from 6 months to 1 year, 1 year to 2 years, and 2 years to 3 years. The percentage of patients achieving 20/25 BSCVA improved from 36.1% at 6 months to 70.4% at 3 years after surgery. A similar increase in the percentage of patients reaching a BSCVA of 20/20 after DSAEK surgery also was observed from 11.1% at 6 months to approximately 47.2% at 3 years.
There is gradual improvement of visual acuity over time after DSAEK surgery for Fuchs' endothelial dystrophy and pseudophakic bullous keratopathy in patients without other vision-limiting ocular comorbidities.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
评估 Descemet 撕囊自动化内皮角膜移植术（DSAEK）术后视力长期改善情况。
回顾性非对照干预性病例系列研究。
108 例因 Fuchs 内皮营养不良和白内障性大泡性角膜病变而接受 DSAEK 手术且无其他眼部合并症的患者，完成了完整的 3 年随访期。
术后最佳矫正视力（BSCVA）分别在术后 6、12、24 和 36 个月记录。使用配对样本 t 检验评估各时间点之间 BSCVA 的改善情况。还进行了亚分析，评估了每个时间点达到 BSCVA 20/20、20/25、20/30 和 20/40 的眼数百分比。
术后 BSCVA 的改善情况。
术后 6 个月、术后 2 年和 3 年时，平均 BSCVA 呈统计学显著趋势改善。从术后 6 个月到 1 年、从 1 年到 2 年以及从 2 年到 3 年，达到 20/20、20/25 和 20/30 视力的眼数比例也在增加。术后 3 年，达到 20/25 BSCVA 的患者比例从术后 6 个月时的 36.1%提高至 70.4%。DSAEK 手术后达到 20/20 BSCVA 的患者比例也从术后 6 个月时的 11.1%增加到术后 3 年时的约 47.2%。
在没有其他视力限制的眼部合并症的患者中，Fuchs 内皮营养不良和白内障性大泡性角膜病变患者接受 DSAEK 手术后，视力会随时间逐渐改善。
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