Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Republic of Singapore.
Exp Cell Res. 2012 Jul 1;318(11):1304-8. doi: 10.1016/j.yexcr.2012.02.006. Epub 2012 Feb 16.
Macroautophagy or autophagy is a self-digesting mechanism that the cellular contents are engulfed by autophagosomes and delivered to lysosomes for degradation. Although it has been well established that autophagy is an important protective mechanism for cells under stress such as starvation via provision of nutrients and removal of protein aggregates and damaged mitochondria, there is a very complex relation between autophagy and cell death. At present, the molecular cross-talk between autophagy and apoptosis has been well discussed, while the relationship between autophagy and programmed necrotic cell death is less understood. In this review we focus on the role of autophagy in necrotic cell death by detailed discussion on two important forms of necrotic cell death: (i) necroptosis and (ii) poly-(ADP-ribose) polymerase (PARP)-mediated cell death. It is believed that one important aspect of the pro-survival function of autophagy is achieved via its ability to block various forms of necrotic cell death.
自噬作用是一种自我消化的机制，其中细胞内容物被自噬体包裹，并被递送至溶酶体进行降解。尽管已经充分证实，自噬作用是细胞在应激（如饥饿）下的一种重要保护机制，因为它可以提供营养物质、清除蛋白质聚集体和受损的线粒体，但自噬作用与细胞死亡之间存在着非常复杂的关系。目前，自噬作用与细胞凋亡之间的分子相互作用已经得到了很好的讨论，而自噬作用与程序性坏死性细胞死亡之间的关系则了解较少。在这篇综述中，我们通过详细讨论两种重要的坏死性细胞死亡形式（即坏死性凋亡和聚（ADP-核糖）聚合酶（PARP）介导的细胞死亡），重点关注自噬作用在坏死性细胞死亡中的作用。据信，自噬作用的一个重要的生存促进功能是通过其阻止各种形式的坏死性细胞死亡的能力来实现的。
