马（Equus caballus）脑脊液中载脂蛋白 HDL 的质谱测量。
Mass spectral measurements of the apoHDL in horse (Equus caballus) cerebrospinal fluid.
机构信息
The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
出版信息
Comp Biochem Physiol Part D Genomics Proteomics. 2012 Jun;7(2):172-4. doi: 10.1016/j.cbd.2012.02.002. Epub 2012 Feb 12.
As a continuation of our proteogenomic studies of equine apolipoproteins, we have obtained molecular masses for several of the apolipoproteins associated with the HDL in horse cerebrospinal fluid (CSF). Using electrospray-ionization mass spectrometry (ESI-MS), we report on values for apolipoproteins, A-I and A-II, as well as acylated apoA-I. In comparison with our previously published data on equine plasma apolipoproteins, there appears to be a higher percentage of acylated apoA-I in the CSF than in plasma. As was the case in plasma, apoA-II circulates as a homodimer. These studies also revealed a protein with a mass of 34,468Da that we are speculating is the value for horse apoE.
作为我们对马载脂蛋白的蛋白质组学研究的延续，我们已经获得了与马脑脊液（CSF）中的高密度脂蛋白（HDL）相关的几种载脂蛋白的分子质量。我们使用电喷雾电离质谱（ESI-MS）报告了载脂蛋白 A-I 和 A-II 以及酰化 apoA-I 的数值。与我们之前发表的马血浆载脂蛋白数据相比，CSF 中的酰化 apoA-I 似乎比血浆中的比例更高。与在血浆中的情况一样，apoA-II 以同源二聚体形式循环。这些研究还揭示了一种质量为 34468Da 的蛋白质，我们推测这是马载脂蛋白 E 的数值。
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