针对N-甲基-D-天冬氨酸受体2B的小分子干扰RNA通过激活丝裂原活化蛋白激酶为多巴胺能神经元提供神经保护作用。
Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase.
作者信息
Ng Olivia T W, Chen L W, Chan Y S, Yung Ken K L
机构信息
Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
出版信息
Neurosignals. 2013;21(1-2):42-54. doi: 10.1159/000334720. Epub 2012 Feb 23.
In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos ameliorated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).
在本研究中，N-甲基-D-天冬氨酸受体2B（NR2B）特异性小干扰RNA（siRNA）被应用于帕金森病模型。我们之前的研究结果表明，通过反义寡核苷酸降低N-甲基-D-天冬氨酸受体的关键亚基N-甲基-D-天冬氨酸受体1（NR1）的表达，可改善6-羟基多巴胺（6-OHDA）损伤大鼠（一种帕金森病（PD）动物模型）的运动症状。
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