交配型转换机制在裂殖酵母中促进 DNA 扩增的惊人高率。
Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.
机构信息
Developmental Genetics Section, Gene Regulation and Chromosome Biology Laboratory, National Institutes of Health, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
出版信息
Genetics. 2012 May;191(1):285-9. doi: 10.1534/genetics.112.138727. Epub 2012 Feb 29.
Abstract
A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.
摘要
一个新型交配型转换缺陷突变体在裂殖酵母中表现出了在交配型位点（mat1）处高度不稳定的重排。该突变是由 mat1 转换现象引起的一段 134bp DNA 片段的局部扩增导致的。我们推测，滚环式复制和同源重组可能是局部基因组区域扩展的普遍机制。
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