Pisani Francesco, Copioli Cristiana, Turco Emanuela Claudia, Sisti Lisa, Cossu Giuseppe, Seri Stefano
Child Neuropsychiatric Unit, University of Parma, Via Gramsci 14, Parma, Italy.
J Child Neurol. 2012 Oct;27(10):1264-9. doi: 10.1177/0883073811435244. Epub 2012 Feb 28.
We analyzed clinical and instrumental data of 403 consecutive newborns with gestational age from 24 to 32 weeks, admitted to the University-Hospital of Parma between January 2000 and December 2007, to evaluate the possible relationship between neonatal mortality and occurrence of neonatal seizures in very preterm newborns. Seventy-four subjects died during hospital stay. Seizures were present in 35 neonates, in whom the mortality rate was 37.1%. Multivariate analysis revealed that birth-weight <1000 g (odds ratio: 4.48; 95% confidence interval: 1.47-13.68; P < .01), cardiopulmonary resuscitation (odds ratio: 5.35; 95% confidence interval: 1.19-23.98; P = .02), and moderately and severely abnormal cerebral ultrasound scan findings (odds ratio: 2.48; 95% confidence interval: 1.02-6.05; P < .04; odds ratio: 9.56; 95% confidence interval: 3.45-26.51; P < .01, respectively) were related to the in-hospital mortality but not the presence of neonatal seizures. Our study suggests that neonatal seizures alone are not an independent risk factor for early death in very preterm newborns.
我们分析了2000年1月至2007年12月期间入住帕尔马大学医院的403例孕周为24至32周的连续新生儿的临床和仪器检查数据，以评估极早产儿的新生儿死亡率与新生儿惊厥发生率之间的可能关系。74名受试者在住院期间死亡。35名新生儿出现惊厥，其死亡率为37.1%。多变量分析显示，出生体重<1000g（比值比：4.48；95%置信区间：1.47 - 13.68；P <.01）、心肺复苏（比值比：5.35；95%置信区间：1.19 - 23.98；P =.02）以及中度和重度异常的脑超声扫描结果（比值比分别为：2.48；95%置信区间：1.02 - 6.05；P <.04；9.56；95%置信区间：3.45 - 26.51；P <.01）与住院死亡率相关，但与新生儿惊厥的存在无关。我们的研究表明，仅新生儿惊厥并非极早产儿早期死亡的独立危险因素。
