Mibu Nobuko, Yokomizo Kazumi, Uchida Wataru, Takemura Satoshi, Zhou Jianrong, Aki Hatsumi, Miyata Takeshi, Sumoto Kunihiro
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Chem Pharm Bull (Tokyo). 2012;60(3):408-14. doi: 10.1248/cpb.60.408.
In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.
在分子对称性和生物活性方面，设计并合成了基于三（2-氨基乙基）胺支架的新型C3和C5对称衍生物。通过蚀斑减少试验评估合成化合物对1型单纯疱疹病毒（HSV-1）的抗病毒活性，并通过对非洲绿猴肾细胞（Vero细胞）评估其细胞毒性活性。大多数化合物没有显示出显著的抗HSV-1活性，但一些对称衍生物显示出高水平的细胞毒性活性。
