肝素诱导的血小板减少症：病例报告与综述
Heparin induced thrombocytopenia: case presentation and review.
作者信息
Cohen Ronny A, Castellano Mariely, Garcia Christine A
机构信息
Woodhull Medical Center, NYU School of Medicine, Brooklyn, NY, USA.
出版信息
J Clin Med Res. 2012 Feb;4(1):68-72. doi: 10.4021/jocmr751w. Epub 2012 Jan 17.
Abstract
UNLABELLED
Heparin Induced Thrombocytopenia (HIT) is an adverse effect of heparin therapy with possibly devastating consequences. We present a case of HIT Type II. An in-depth review of HIT is presented, examining the important clinical symptoms and diagnostic indicators. The treatment of HIT is then discussed, with an emphasis on current therapies. An extensive literature review has been performed to present a comprehensive review of the causes, pathophysiology and treatment of HIT.
KEYWORDS
Heparin induced thrombocytopenia; Anticoagulation; PF4; HIT.
摘要
未标注
肝素诱导的血小板减少症（HIT）是肝素治疗的一种不良反应，可能会产生严重后果。我们报告一例II型HIT病例。本文对HIT进行了深入综述，探讨了重要的临床症状和诊断指标。随后讨论了HIT的治疗方法，重点介绍了当前的治疗手段。通过广泛的文献综述，对HIT的病因、病理生理学和治疗方法进行了全面的阐述。
关键词
肝素诱导的血小板减少症；抗凝；PF4；HIT。
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本文引用的文献
1
Incidence of thrombocytopenia in hospitalized patients with venous thromboembolism.
Am J Med. 2009 Oct;122(10):919-30. doi: 10.1016/j.amjmed.2009.03.026. Epub 2009 Aug 13.
2
A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia.
Am J Med. 2008 Jul;121(7):632-6. doi: 10.1016/j.amjmed.2008.03.012.
3
Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Chest. 2008 Jun;133(6 Suppl):340S-380S. doi: 10.1378/chest.08-0677.
4
The approach to heparin-induced thrombocytopenia.
Semin Respir Crit Care Med. 2008 Feb;29(1):66-74. doi: 10.1055/s-2008-1047564.
5
Heparin-induced thrombocytopenia: treatment options and special considerations.
Pharmacotherapy. 2007 Apr;27(4):564-87. doi: 10.1592/phco.27.4.564.
6
Heparin-induced thrombocytopenia in the critical care setting: diagnosis and management.
Crit Care Med. 2006 Dec;34(12):2898-911. doi: 10.1097/01.CCM.0000248723.18068.90.
7
Heparin-induced thrombocytopenia Type II in subarachnoid hemorrhage patients: incidence and complications.
Neurosurgery. 2005 Aug;57(2):243-8; discussion 243-8. doi: 10.1227/01.neu.0000166539.02280.e5.
8
Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis.
Blood. 2005 Oct 15;106(8):2710-5. doi: 10.1182/blood-2005-04-1546. Epub 2005 Jun 28.
9
When heparins promote thrombosis: review of heparin-induced thrombocytopenia.
Circulation. 2005 May 24;111(20):2671-83. doi: 10.1161/CIRCULATIONAHA.104.518563.
10
Delayed-onset heparin-induced thrombocytopenia.
Ann Emerg Med. 2005 Apr;45(4):417-9. doi: 10.1016/j.annemergmed.2004.08.005.
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